氯磺丙脲

概览

Chlorpropamide is a sulfonylurea used in the treatment of non insulin dependent diabetes mellitus.

作用机制

Sulfonylureas such as chlorpropamide bind to ATP-sensitive potassium channels on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Depolarization stimulates calcium ion influx through voltage-sensitive calcium channels, raising intracellular concentrations of calcium ions, which induces the secretion, or exocytosis, of insulin.

适应症

For treatment of NIDDM in conjunction with diet and exercise.

• Diabetes Insipidus
• Type 2 Diabetes Mellitus