Efavirenz

Generic Name
Efavirenz
Brand Names
Atripla, Stocrin, Sustiva, Symfi, Efavirenz Teva
Drug Type
Small Molecule
Chemical Formula
C14H9ClF3NO2
CAS Number
154598-52-4
Unique Ingredient Identifier
JE6H2O27P8
Background

Efavirenz (brand names Sustiva® and Stocrin®) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) and is used as part of highly active antiretroviral therapy (HAART) for the treatment of a human immunodeficiency virus (HIV) type 1.
...

Indication

For use in combination treatment of HIV infection (AIDS)

Associated Conditions
Human Immunodeficiency Virus Type 1 (HIV-1) Infection
Associated Therapies
-

ABT-378/Ritonavir and Efavirenz in HIV-Infected Patients Who Have Taken More Than One Protease Inhibitor in the Past

Phase 2
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2005-06-24
Lead Sponsor
ViRx
Registration Number
NCT00004582
Locations
🇺🇸

ViRx Inc, San Francisco, California, United States

The Effectiveness of Nelfinavir and Efavirenz, Used Alone or Together, Combined With Other Anti-HIV Drugs in Patients Who Have Taken Anti-HIV Drugs

Phase 2
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2021-11-01
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
300
Registration Number
NCT00001087
Locations
🇺🇸

Rush Univ. Med. Ctr. ACTG CRS, Chicago, Illinois, United States

🇺🇸

Cook County Hosp. CORE Ctr., Chicago, Illinois, United States

🇺🇸

Johns Hopkins Adult AIDS CRS, Baltimore, Maryland, United States

and more 3 locations

Safety, Tolerability, and Anti-HIV Activity of DMP 266 (Efavirenz) in Combination With Nelfinavir in HIV-Positive Children

Phase 1
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2021-10-29
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
103
Registration Number
NCT00000893
Locations
🇺🇸

The Children's Hosp. of Philadelphia IMPAACT CRS, Philadelphia, Pennsylvania, United States

🇺🇸

UCLA-Los Angeles/Brazil AIDS Consortium (LABAC) CRS, Los Angeles, California, United States

🇺🇸

Bronx-Lebanon Hosp. IMPAACT CRS, Bronx, New York, United States

and more 24 locations

Effect of a Change in HIV Therapy on Liver Steatosis, Inflammation, and Fibrosis

Not Applicable
Withdrawn
Conditions
First Posted Date
2001-08-31
Last Posted Date
2015-03-09
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Registration Number
NCT00023218
Locations
🇺🇸

Univ of Hawaii, Honolulu, Hawaii, United States

🇺🇸

Beth Israel Med Ctr, New York, New York, United States

🇺🇸

Tripler Army Med Ctr, Tripler AMC, Hawaii, United States

A Study of the Safety and Effectiveness of Combination Anti-HIV Therapy in HIV-Infected Adults

Phase 4
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2005-06-24
Lead Sponsor
Glaxo Wellcome
Target Recruit Count
40
Registration Number
NCT00004585
Locations
🇺🇸

George Washington Univ Med Ctr, Washington, District of Columbia, United States

🇺🇸

Tower Infectious Diseases / Med Associates Inc, Los Angeles, California, United States

🇺🇸

North Shore Univ Hosp, Manhasset, New York, United States

and more 2 locations

Intensive Pharmacokinetics of the Nelfinavir-Rifabutin Interaction in Patients With HIV-Related Tuberculosis Treated With a Rifabutin-Based Regimen

Not Applicable
Conditions
First Posted Date
2001-07-04
Last Posted Date
2005-06-24
Lead Sponsor
National Center for Research Resources (NCRR)
Registration Number
NCT00018083
Locations
🇺🇸

Duke University Medical Center, Durham, North Carolina, United States

A Study to Determine How and Why HIV-Infected Subjects on Anti-viral Treatment Develop Lipodystrophy

Phase 4
Completed
Conditions
First Posted Date
2000-08-28
Last Posted Date
2010-03-02
Lead Sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Registration Number
NCT00006190
Locations
🇺🇸

UT Southwestern Medical Center, Dallas, Texas, United States

Continued Antiretroviral Therapy With Abacavir, Amprenavir and Efavirenz

Phase 2
Completed
Conditions
First Posted Date
1999-11-04
Last Posted Date
2008-03-04
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
25
Registration Number
NCT00001758
Locations
🇺🇸

National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, Maryland, United States

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