Nitazoxanide

Generic Name: Nitazoxanide

Brand Names: Alinia, Busulfex

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₉N_₃O_₅S

CAS Number: 55981-09-4

Unique Ingredient Identifier: SOA12P041N

Background: Nitazoxanide belongs to the class of drugs known as thiazolides. Nitazoxanide (NTZ) is a broad-spectrum anti-infective drug that markedly modulates the survival, growth, and proliferation of a range of extracellular and intracellular protozoa, helminths, anaerobic and microaerophilic bacteria, in addition to viruses. This drug is effective in the treatment of gastrointestinal infections including Cryptosporidium parvum or Giardia lamblia in healthy subjects. It is generally well tolerated. Nitazoxanide is a first-line, standard treatment for illness caused by C. parvum or G. lamblia infection in healthy (not immunosuppressed) adults and children and may also be considered in the treatment of illnesses caused by other protozoa or helminths . Recently, this drug has been studied as a broad-spectrum antiviral agent due to its ability to inhibit the replication of several RNA and DNA viruses .

Indication: 用于治疗隐孢子虫、贾第鞭毛虫、阿米巴原虫引起的原虫性腹泻。

Associated Conditions: Diarrhea caused by Cryptosporidium parvum, Diarrhea caused by Giardia lamblia

Associated Therapies: -

Clinical Trials

Study of Nitazoxanide (NTZ) Based New Therapeutic Regimens for Helicobacter Pylori

Phase 3

Conditions: Helicobacter-associated Gastritis

Interventions: Drug: Metronidazole(MTZ)
Drug: Nitazoxanide
Drug: Omeprazole
Drug: Clarithromycin
Drug: Levofloxacin
Drug: Doxicycline

First Posted Date: 2015-04-21

Last Posted Date: 2017-04-25

Lead Sponsor: Sherief Abd-Elsalam

Target Recruit Count: 120

Registration Number: NCT02422706

Locations: 🇪🇬
Tanta university hospital, Cairo, Egypt

The Effects of Nitazoxanide in Hepatic Encephalopathy

Phase 2

Conditions: Hepatic Encephalopathy

Interventions: Drug: Nitazoxanide
Drug: Oral lactulose
Drug: Metronidazole
Drug: Rifaximine

First Posted Date: 2015-01-08

Last Posted Date: 2015-01-08

Lead Sponsor: Ain Shams University

Target Recruit Count: 36

Registration Number: NCT02334163

Locations: 🇪🇬
Faculty of medicine, Ain Shams University, Cairo, Egypt

Oral Nitazoxanide in Acute Gastroenteritis in Australian Indigenous Children

Phase 2

Terminated

Conditions: Gastroenteritis

Interventions: Drug: placebo
Drug: Nitazoxanide

First Posted Date: 2014-06-18

Last Posted Date: 2024-02-08

Lead Sponsor: Telethon Kids Institute

Target Recruit Count: 216

Registration Number: NCT02165813

Locations: 🇦🇺
Alice Springs Hospital, Alice Springs, Northern Territory, Australia
🇦🇺
Royal Darwin Hospital, Darwin, Northern Territory, Australia

Nitazoxanide Versus Placebo for the Treatment of Hospitalized Subjects With Severe Acute Respiratory Illness

Phase 2

Completed

Conditions: Severe Acute Respiratory Illness

Interventions: Drug: Placebo
Drug: Nitazoxanide

First Posted Date: 2014-02-07

Last Posted Date: 2018-08-01

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Target Recruit Count: 260

Registration Number: NCT02057757

Locations: 🇲🇽
Hospital Central Dr. Ignacio Morones Prieto, San Luis Potosi, Mexico
🇲🇽
Instituto Nacional de Pediatria, Coyoacan, Mexico
🇲🇽
Hospital General Dr. Aurelio Valdivieso, Oaxaca, Mexico

and more 3 locations

The Role Of Nitazoxanide, Interferon Alfa And Ribavirin In Treatment Of Hepatitis C Infected Type 2 Diabetic Patients

Phase 4

Completed

Conditions: Hepatitis C, Chronic
DIABETES MELLITUS Type 2

Interventions: Drug: nitazoxanide
Drug: conventional interferon alfa
Drug: Ribavirin

First Posted Date: 2013-01-17

Last Posted Date: 2013-09-20

Lead Sponsor: Services Institute of Medical Sciences, Pakistan

Target Recruit Count: 66

Registration Number: NCT01770483

Locations: 🇵🇰
Endocrinology and Diabetes management centre, Lahore, Punjab, Pakistan

Irritable Bowel Syndrome Evaluation and Treatment in Primary Care

Phase 4

Completed

Conditions: Irritable Bowel Syndrome

Interventions: Drug: Placebo
Drug: Bifidobacterium infantis
Drug: Pancrelipase
Drug: Nitazoxanide

First Posted Date: 2012-07-16

Last Posted Date: 2019-01-23

Lead Sponsor: American Academy of Family Physicians

Target Recruit Count: 61

Registration Number: NCT01641341

Locations: 🇺🇸
Baton Rouge Family Practice, Baton Rouge, Louisiana, United States
🇺🇸
American Academy of Family Physicians-National Research Network, Leawood, Kansas, United States
🇺🇸
Torrance Clinical Research, Lomita, California, United States

and more 6 locations

Safety and Efficacy Study of Nitazoxanide in the Treatment of Acute Uncomplicated Influenza

Phase 3

Completed

Conditions: Influenza

Interventions: Drug: Nitazoxanide
Drug: Oseltamivir
Drug: Placebo Oral Tablet
Drug: Placebo Oral Capsule

First Posted Date: 2012-06-01

Last Posted Date: 2018-03-29

Lead Sponsor: Romark Laboratories L.C.

Target Recruit Count: 1941

Registration Number: NCT01610245

Locations: 🇦🇺
Influence Study SIte, Nedlands, Western Australia, Australia
🇳🇿
Influence Study Site, Christchurch Central, Christchurch, New Zealand