Overview
Rocuronium (rapid onset-curonium) is a desacetoxy analogue of vecuronium with a more rapid onset of action. It is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Introduced in 1994, rocuronium has rapid onset, and intermediate duration of action. It is commonly marketed under the trade names Zemuron and Esmeron. The drug is associated with the risk of developing allergic reactions in some high-risk patients, such as those with asthma. However, there was a similar incidence of allergic reactions associated with other non-depolarizing neuromuscular blocking agents. Sugammadex is a γ-cyclodextrin derivative that has been introduced as a novel agent to reverse the action of rocuronium.
Background
Rocuronium (rapid onset-curonium) is a desacetoxy analogue of vecuronium with a more rapid onset of action. It is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Introduced in 1994, rocuronium has rapid onset, and intermediate duration of action. It is commonly marketed under the trade names Zemuron and Esmeron. The drug is associated with the risk of developing allergic reactions in some high-risk patients, such as those with asthma. However, there was a similar incidence of allergic reactions associated with other non-depolarizing neuromuscular blocking agents. Sugammadex is a γ-cyclodextrin derivative that has been introduced as a novel agent to reverse the action of rocuronium.
Indication
For inpatients and outpatients as an adjunct to general anesthesia to facilitate both rapid sequence and routine tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
Associated Conditions
- Muscle fasciculation caused by succinylcholine
Clinical Trials
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Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2016/01/06 | Phase 4 | UNKNOWN | Ajou University School of Medicine | ||
2015/12/30 | Phase 4 | Completed | Ajou University School of Medicine | ||
2015/12/18 | Phase 3 | UNKNOWN | Diskapi Yildirim Beyazit Education and Research Hospital | ||
2015/12/16 | Phase 4 | Completed | Uludag University | ||
2015/11/10 | Not Applicable | UNKNOWN | |||
2015/10/28 | Phase 4 | Recruiting | |||
2015/10/26 | Phase 4 | UNKNOWN | |||
2015/10/14 | Not Applicable | Completed | |||
2015/09/17 | Phase 4 | Completed | Leiden University Medical Center | ||
2015/09/11 | Not Applicable | Completed | Brno University Hospital |
FDA Drug Approvals
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|---|---|---|---|---|---|
| No FDA approvals found for this drug. | |||||
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| No EMA approvals found for this drug. | |||
HSA Drug Approvals
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NMPA Drug Approvals
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