Rocuronium

Overview

Rocuronium (rapid onset-curonium) is a desacetoxy analogue of vecuronium with a more rapid onset of action. It is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Introduced in 1994, rocuronium has rapid onset, and intermediate duration of action. It is commonly marketed under the trade names Zemuron and Esmeron. The drug is associated with the risk of developing allergic reactions in some high-risk patients, such as those with asthma. However, there was a similar incidence of allergic reactions associated with other non-depolarizing neuromuscular blocking agents. Sugammadex is a γ-cyclodextrin derivative that has been introduced as a novel agent to reverse the action of rocuronium.

Background

Indication

For inpatients and outpatients as an adjunct to general anesthesia to facilitate both rapid sequence and routine tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation.

Associated Conditions

Muscle fasciculation caused by succinylcholine

Title	Posted	Study ID	Phase	Status	Sponsor
Optimal Inspiratory Pressure for Facemask Pressure-controlled Ventilation in Children	2015/06/15	NCT02471521	Not Applicable	Completed	Seoul National University Hospital
Respiratory Mechanics and Metabolic Changes During Low Pressure Laparoscopic Cholecystectomy	2015/06/12	NCT02469831	Phase 2	Completed	Assiut University
The Effect of no Muscle Relaxant Versus Reduced-dose Rocuronium on Anesthesia in Adenotonsillectomy	2015/06/10	NCT02467595	Phase 4	UNKNOWN	Korea University Anam Hospital
Comparision Between Hemodynamic Response of Dexmedetomidine and Remifentanil on Anesthesia in Endoscopic Sinus Surgery	2015/06/08	NCT02464722	Phase 4	UNKNOWN	Korea University Anam Hospital
Deep vs Moderate Neuromuscular Blockade With Rocuronium in Patients Undergoing Endolaryngeal Procedures	2015/05/21	NCT02451202	Phase 4	Completed	Chulalongkorn University
Sugammadex Versus Neostigmine in Patients With Liver Cirrhosis Undergoing Liver Resection	2015/04/13	NCT02414880	Phase 4	Completed	Cairo University
Rocuronium + Sugammadex vs. Succinylcholine + Cisatracurium + Neostigmine/Atropine in Obese Participants (MK-8616-104)	2015/04/07	NCT02410590	Phase 4	Withdrawn	Merck Sharp & Dohme LLC
The Necessity of Routine Mask Ventilation in Adults	2015/03/27	NCT02400931	Not Applicable	Completed	Yonsei University
Effects of Nonintubated Versus Intubated General Anesthesia on Recovery After Thoracoscopic Lung Resection	2015/03/19	NCT02393664	Phase 2	UNKNOWN	National Taiwan University Hospital
Pharmacokinetic and Pharmacodynamic of Rocuronium	2015/03/03	NCT02376595	N/A	Completed	Pontificia Universidad Catolica de Chile

Title

Posted

Study ID

Phase

Status

Sponsor

Optimal Inspiratory Pressure for Facemask Pressure-controlled Ventilation in Children

2015/06/15

NCT02471521

Not Applicable

Completed

Seoul National University Hospital