Rocuronium

Generic Name
Rocuronium
Brand Names
-
Drug Type
Small Molecule
Chemical Formula
C32H53N2O4
CAS Number
143558-00-3
Unique Ingredient Identifier
WRE554RFEZ
Background

Rocuronium (rapid onset-curonium) is a desacetoxy analogue of vecuronium with a more rapid onset of action. It is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Introduced in 1994, rocuronium has rapid onset, and intermediate duration of action. It is commonly marketed under the trade names Zemuron and Esmeron. The drug is associated with the risk of developing allergic reactions in some high-risk patients, such as those with asthma. However, there was a similar incidence of allergic reactions associated with other non-depolarizing neuromuscular blocking agents. Sugammadex is a γ-cyclodextrin derivative that has been introduced as a novel agent to reverse the action of rocuronium.

Indication

For inpatients and outpatients as an adjunct to general anesthesia to facilitate both rapid sequence and routine tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation.

Associated Conditions
Muscle fasciculation caused by succinylcholine
Associated Therapies
Curarization therapy, Neuromuscular blocking therapy, Facilitation of small bowel intubation therapy

The Neuromuscular Effect of Rocuronium in Patient

Not Applicable
Conditions
Interventions
First Posted Date
2016-01-15
Last Posted Date
2016-02-17
Lead Sponsor
Go Eun Bae
Target Recruit Count
80
Registration Number
NCT02657187
Locations
🇰🇷

Korea university anam hospital, Seoul, Korea, Republic of

The Effect of Different Dose of Ketamine With Low Dose Rocuronium in Children

First Posted Date
2016-01-06
Last Posted Date
2016-01-06
Lead Sponsor
Ajou University School of Medicine
Target Recruit Count
60
Registration Number
NCT02646709

Stylet Use for McGrath Videolaryngoscope

First Posted Date
2015-12-30
Last Posted Date
2016-11-23
Lead Sponsor
Ajou University School of Medicine
Target Recruit Count
140
Registration Number
NCT02642367
Locations
🇰🇷

Ajou University Hospital, Suwon, Korea, Republic of

Cognitive Functions After TIVA With Dexmedetomidine

First Posted Date
2015-12-16
Last Posted Date
2024-05-17
Lead Sponsor
Uludag University
Target Recruit Count
40
Registration Number
NCT02631135
Locations
🇹🇷

Uludag University, Bursa, Turkey

Compare of Surgical Condition and Complications With Moderate and Deep NM Block

First Posted Date
2015-11-10
Last Posted Date
2015-11-10
Lead Sponsor
Chonnam National University Hospital
Target Recruit Count
80
Registration Number
NCT02601508
Locations
🇰🇷

Chonnam University Hwasun Hospital, Hwasun, Korea, Republic of

Neuromuscular-Blocking Agents and Hypoxemia During Intubation in Infants (ROC-HYPOX)

Phase 4
Recruiting
Conditions
Interventions
First Posted Date
2015-10-28
Last Posted Date
2023-07-18
Lead Sponsor
Fondation Ophtalmologique Adolphe de Rothschild
Target Recruit Count
412
Registration Number
NCT02589691
Locations
🇫🇷

Hôpital Fondation Adolphe de Rothschild, Paris, France

🇫🇷

Hopital Robert Debre, Paris, France

🇫🇷

Centre Hospitalier Intercommunal Creteil (CHIC), Créteil, France

and more 3 locations

Evaluation of EEG With Respect to the Change of Depth of Anesthesia During General Anesthesia

First Posted Date
2015-10-26
Last Posted Date
2015-11-04
Lead Sponsor
Korea University Anam Hospital
Target Recruit Count
40
Registration Number
NCT02586441

Effect of Deep Neuromuscular Block on Surgical Conditions in Morbidly Obese Patients

Phase 4
Completed
Conditions
Interventions
First Posted Date
2015-09-17
Last Posted Date
2017-02-03
Lead Sponsor
Leiden University Medical Center
Target Recruit Count
109
Registration Number
NCT02553629
Locations
🇳🇱

Medisch Centrum Haaglanden / Nederlandse Obesitas Kliniek, The Hague, Zuid Holland, Netherlands

🇳🇱

Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands

The Effects of Remifentanil and Remifentanil-Alfentanil Administration in Children

First Posted Date
2015-07-01
Last Posted Date
2015-07-07
Lead Sponsor
Hallym University Medical Center
Target Recruit Count
102
Registration Number
NCT02486926
© Copyright 2024. All Rights Reserved by MedPath