Ondansetron

Generic Name
Ondansetron
Brand Names
Zofran, Zuplenz
Drug Type
Small Molecule
Chemical Formula
C18H19N3O
CAS Number
99614-02-5
Unique Ingredient Identifier
4AF302ESOS
Background

A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.
...

Indication

In the adult patient population:

i) orally administered ondansetron tablets and orally disintegrating tablets (ODT) are indicated for:

- the prevention of nausea and vomiting associated with emetogenic cancer chemotherapy, including high dose (ie. greater than or equal to 50 mg/m2) cisplatin therapy, and radiotherapy, and
...

Associated Conditions
Chemotherapy-Induced Nausea and Vomiting, Cholestatic pruritus, Post Operative Nausea and Vomiting (PONV), Radiation-Induced Nausea and Vomiting, Uremic Pruritus, Severe Hyperemesis gravidarum
Associated Therapies
-
Clinical Trials
Related News

Ondansetron Versus Dexamethasone/Ondansetron to Treat Acute Nausea in the Emergency Department

Phase 4
Terminated
Conditions
Nausea
Abdominal Pain
Interventions
Drug: Ondansetron
Drug: Dexamethasone
First Posted Date
2016-12-07
Last Posted Date
2018-09-26
Lead Sponsor
OhioHealth
Target Recruit Count
127
Registration Number
NCT02985840
Locations
🇺🇸

OhioHealth Doctors Hospital, Columbus, Ohio, United States

Study to Evaluate the Effect of Aprepitant in Children and Adolescents Receiving AML Remission Induction Chemotherapy

First Posted Date
2016-12-01
Last Posted Date
2017-01-25
Lead Sponsor
Dr Atul Sharma
Target Recruit Count
116
Registration Number
NCT02979548
Locations
🇮🇳

Irch, Aiims , New Delhi , India, New Delhi, DEL, India

Prophylactic Ondansetron in Post-op Cardiac Surgery Patients to Prevent Post-operative Nausea and Vomiting

Not Applicable
Completed
Conditions
Postoperative Nausea and Vomiting
Interventions
Drug: Saline
Drug: Ondansetron
First Posted Date
2016-11-17
Last Posted Date
2018-10-15
Lead Sponsor
University of British Columbia
Target Recruit Count
186
Registration Number
NCT02966041
Locations
🇨🇦

St. Paul's Hospital, Vancouver, British Columbia, Canada

Acupuncture Point P6 Stimulation for Reduction of Nausea and Vomiting During Cesarean

First Posted Date
2016-11-09
Last Posted Date
2017-09-25
Lead Sponsor
Rutgers, The State University of New Jersey
Target Recruit Count
180
Registration Number
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Locations
🇺🇸

Robert Wood Johnson University Hospital, New Brunswick, New Jersey, United States

Norepinephrine Consumption After Prophylactic Ondansetron

Phase 4
Completed
Conditions
Maternal Hypotension
Interventions
Drug: Saline
Drug: Ondansetron
First Posted Date
2016-10-10
Last Posted Date
2017-08-22
Lead Sponsor
Cukurova University
Target Recruit Count
108
Registration Number
NCT02928601
Locations
🇹🇷

Çukurova University, Adana, Turkey

Reduction in Spinal-induced Hypotension With Ondansetron in Parturients Undergoing Caesarean Section

Phase 4
Completed
Conditions
Hypotension
Interventions
Drug: Normal saline
Drug: Ondansetron
First Posted Date
2016-09-26
Last Posted Date
2019-08-28
Lead Sponsor
Assiut University
Target Recruit Count
160
Registration Number
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Locations
🇪🇬

Assiut University hospital, Assiut, Asyut Governorate, Egypt

CSF Pharmacokinetics of Ondansetron

Not Applicable
Completed
Conditions
Pain
Interventions
Drug: Ondansetron
First Posted Date
2016-09-15
Last Posted Date
2019-12-27
Lead Sponsor
Washington University School of Medicine
Target Recruit Count
19
Registration Number
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Locations
🇺🇸

Washington University in St. Louis, Saint Louis, Missouri, United States

The Effect of Preventive Use of Ondansetron in the Cesarean Section Under Spinal Anesthesia

First Posted Date
2016-08-30
Last Posted Date
2016-08-31
Lead Sponsor
Bnai Zion Medical Center
Target Recruit Count
100
Registration Number
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Locations
🇮🇱

Luis A Gaitini M.D., Haifa, Israel

Interest of Intravenous Ondansetron in the Prevention of Spinal Anaesthesia-induced Hypotension in Caesarean Section

First Posted Date
2016-08-11
Last Posted Date
2016-08-11
Lead Sponsor
Centre Hospitalier Universitaire Dijon
Target Recruit Count
7
Registration Number
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Locations
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CHU Dijon Bourgogne, Dijon, France

Effect of Ramosetron in Prevention of Intrathecal Morphine Induced Nausea and Vomiting

First Posted Date
2016-07-13
Last Posted Date
2016-07-13
Lead Sponsor
Thammasat University
Target Recruit Count
99
Registration Number
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