Propacetamol

Overview

Propacetamol is a non-opioid analgesic devoid of the major contraindications. It is a derivative of acetaminophen, or paracetamol, with the molecular formula glycine, N, N-diethyl-,4-(acetylamino)phenyl ester. Propacetamol is a parenteral formulation of paracetamol and thus, it is a prodrug that is completely hydrolyzed to paracetamol. It is not available in the United States but this prodrug has been widely used in other countries such as France since 1985.

Indication

Propacetamol is a paracetamol prodrug of intravenous administration used to control fever and pain of perioperative period in multimodal analgesia therapy.

Associated Conditions

No associated conditions information available.

Clinical Trials

Title	Posted	Study ID	Phase	Status	Sponsor
Propacetamol to Reduce Post Cesarean Section Uterine Contraction Pain	2019/03/18	NCT03878082	Not Applicable	Completed	Mackay Memorial Hospital
Comparison of the Effect of Propacetamol, Ibuprofen or Their Combination on Postoperative Pain and Quality of Recovery After Laparoscopic Hernia Repair in Children	2017/11/24	NCT03352362	Not Applicable	Completed	Yonsei University
Combination Effect of Nefopam With Propacetamol for Postoperative Pain After Thyroidectomy	2015/10/16	NCT02577068	Not Applicable	Completed	Yonsei University
The Effect of Additional Propacetamol Infusion on Post Procedural Outcome and Opioid Consumption During Catheter Ablation of Atrial Fibrillation.	2015/08/04	NCT02515188	Not Applicable	Completed	Yonsei University
Dexamethasone Versus Local Infiltration Technique for Tonsillectomy in Children	2015/02/04	NCT02355678	Not Applicable	Completed	Makassed General Hospital
The Opioid-sparing Effect and Reduced PONV Using Propacetamol in PCA Among Patients With High Risk of PONV	2014/04/16	NCT02116257	Not Applicable	Completed	Yonsei University
A Comparison of Nefopam-propacetamol Combination and Propacetamol for Postoperative Quality of Recovery After Laparoscopic Nephrectomy	2013/04/17	NCT01833728	Not Applicable	Completed	Yonsei University

FDA Drug Approvals

Approved Product	Manufacturer	NDC Code	Route	Strength	Effective Date
No FDA approvals found for this drug.

EMA Drug Approvals

Approved Product	Authorization Holder	Status	Issued Date
No EMA approvals found for this drug.

HSA Drug Approvals

Approved Product	Manufacturer	Approval Number	Dosage Form	Strength	Approval Date
No HSA approvals found for this drug.

NMPA Drug Approvals

Approved Product	Company	Approval Number	Drug Type	Dosage Form	Approval Date
Propacetamol Hydrochloride for Injection	吉林敖东洮南药业股份有限公司	国药准字H20065754	化学药品	注射剂	10/9/2023
Propacetamol Hydrochloride for Injection	西藏诺泽生物医药有限公司	国药准字H20084014	化学药品	注射剂	6/6/2024
Propacetamol Hydrochloride for Injection	山西振东泰盛制药有限公司	国药准字H20066517	化学药品	注射剂	1/7/2021
Propacetamol Hydrochloride for Injection	吉林敖东洮南药业股份有限公司	国药准字H20065755	化学药品	注射剂	9/13/2023
Propacetamol Hydrochloride for Injection	山西振东泰盛制药有限公司	国药准字H20066516	化学药品	注射剂	1/7/2021
Propacetamol Hydrochloride for Injection	瑞阳制药股份有限公司	国药准字H20083993	化学药品	注射剂	6/24/2023
Propacetamol Hydrochloride for Injection	贵州润生制药有限公司	国药准字H20066535	化学药品	注射剂	4/29/2021
Propacetamol Hydrochloride for Injection	海南皇隆制药股份有限公司	国药准字H20083986	化学药品	注射剂	11/21/2022
Propacetamol Hydrochloride for Injection	海口奇力制药股份有限公司	国药准字H20084008	化学药品	注射剂	3/27/2023
Propacetamol Hydrochloride for Injection	海南全星制药有限公司	国药准字H20057729	化学药品	注射剂	7/28/2020

PPB Drug Approvals

Approved Product	Registration No.	Company	Licence No.	Strength	Registration Date
No PPB approvals found for this drug.

TGA Drug Approvals

Approved Product	ARTG ID	Sponsor	Registration Type	Status	Registration Date
No TGA approvals found for this drug.

AI-Powered Research

Premium Access