尼索地平 (Sular)

概览

Nisoldipine is a calcium channel blocker used as monotherapy or combined with other drugs for the treatment of hypertension.

作用机制

By deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, Nisoldipine inhibits the influx of extracellular calcium across the myocardial and vascular smooth muscle cell membranes The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.

适应症

For the treatment of hypertension. It may be used alone or in combination with other antihypertensive agents.

• Hypertension