喹高利特

概览

Quinagolide is a dopamine D2 receptor agonist used for the treatment of hyperprolactinemia.

作用机制

Prolactin secretion from the lactotroph cells present in the anterior pituiatry gland is under tonic inhibitory control mediated by dopaminergic signalling via D2 receptors . Quinagolide selectively binds to D2 receptors expressed on the surface of lactotroph cells with high affinity which results in reduced adenylyl cyclase activity, reduced intracellular cyclic adenosine monophosphate and inhibited prolactin secretion. It also binds to D1 receptors but with low affinity and little clinical relevance .

适应症

用于治疗伴有高泌乳素血症的帕金森病，血催乳激素过多症（原发的或者是因分泌催乳激素的垂体微小腺瘤或巨腺瘤），也用于治疗肢端肥大症。

• Hyperprolactinemia
• Idiopathic Hyperprolactinemia