Aspirin

Green Bay Packers QB Jordan Love wore a Brett Favre jersey to Lambeau Field, showing support after Favre's Parkinson's diagnosis. Favre, who suffered over 1,000 concussions, believes head trauma led to his condition. The NFL continues efforts to reduce concussion risks.

Dr Victoria Kunene, a consultant medical oncologist at Queen Elizabeth Hospital Birmingham, is spearheading personalized mRNA vaccines for colorectal cancer as part of the NHS Cancer Vaccine Launch Pad initiative. These vaccines aim to prevent and treat cancer by re-educating the immune system to recognize and eliminate cancer cells. The trial focuses on high-risk stage two and three colon cancer patients with detectable circulating tumour DNA, offering them a bespoke vaccine after standard chemotherapy. The initiative seeks to improve patient outcomes and survival rates by integrating advanced genomic sequencing and immunotherapy.

Dr. Jin Wang's Center for NextGen Therapeutics at Baylor College of Medicine focuses on developing multispecific drugs using advanced proteomics, aiming to accelerate novel therapeutic discovery for unmet medical needs. The center acts as a matchmaker, providing molecules for researchers and facilitating collaborative co-development. Wang's background in drug discovery, including targeted protein degraders and antibody drug conjugates, led to the center's creation, aligning with the fourth wave of biopharmaceutical industry innovation.

The FDA approved self-administered nasal spray flu vaccine FluMist for adults and caregivers, available for ages 2-49. It contains live-attenuated virus, effective at 45%, similar to flu shots. Home use expected by 2025, currently administered by health providers. Not recommended for pregnant women, immune-compromised, or those on aspirin. Side effects include nasal congestion and fever. Easy self-administration aims to boost vaccination rates.

A study in CANCER found higher risks of stroke, heart attack, and heart failure hospitalization in older cancer survivors, with chemotherapy linked to elevated rates. Cardiovascular disease incidence was greatest in patients with metastatic, blood, and lung cancers. Early screening and preventive measures are crucial for mitigating these risks.

Dr. Rozalina McCoy discusses CGM innovations from the ATTD 2024 Conference, focusing on CGM diabetes quality measures, hypoglycemia progress, and CGM-guided precision diabetes management. She highlights the utility of CGM data, the importance of detecting hypoglycemia, and the role of CGM in guiding nutrition and exercise for diabetes management, emphasizing the complementary use of A1c and CGM data for patient care.

New migraine drugs like rimegepant and ubrogepant are no more effective than traditional painkillers and even less so than triptans, according to a global analysis. Triptans are recommended as the first line of treatment, with traditional painkillers as a second option for those unable to take triptans due to heart problems.

A study in the American Journal of Obstetrics & Gynecology found that a single aspirin dose during pregnancy is linked to plasma salicylic acid, thromboxane suppression, and platelet inhibition, with variable efficacy. The study recommends aspirin dose modification for optimal response.

UK researchers emulated an RCT comparing blood thinners using real-world data, finding similar treatment effects but noting differences in patient demographics and medication use. This approach aims to fill evidence gaps for underrepresented groups in RCTs.

Lipophilic statins reduce HCC risk; hydrophilic statins, aspirin, and metformin do not. A clinical trial (NCT05028829) is ongoing to confirm benefits of atorvastatin.