Metaraminol

Overview

An adrenergic agonist that acts predominantly at alpha adrenergic receptors and also stimulates the release of norepinephrine. It has been used primarily as a vasoconstrictor in the treatment of hypotension.

Indication

For the treatment and prevention of hypotension due to hemorrhage, spinal anesthesia, and shock associated with brain damage

Associated Conditions

No associated conditions information available.

Clinical Trials

Title	Posted	Study ID	Phase	Status	Sponsor
Effect of 90% Effective Dose of Metaraminol in Supine and Left Tilt Positions on Cesarean Section	2021/10/20	NCT05084599	Phase 4	Completed	Peking University People's Hospital
Effect of Three Weight-adjusted Vasopressors for Elective Cesarean Delivery	2021/08/05	NCT04991662	Phase 4	Completed	Xuzhou Medical University
Ephedrine, Phenylephrine and Metaraminol Effects on Maternal Cardiac Output, Uterine Blood Flow and Fetal Circulation	2014/09/19	NCT02245191	Not Applicable	UNKNOWN	University of Sao Paulo General Hospital
Maternal and Neonatal Outcomes of the Use of Vasopressors to Treat Hypotension During Spinal Anesthesia for Cesarean	2011/10/13	NCT01451060	Phase 3	Withdrawn	Instituto Materno Infantil Prof. Fernando Figueira
Up-Down Determination of the ED90 of Metaraminol to Treat Hypotension During Cesarean Section	2010/04/22	NCT01108874	Phase 2	Completed	Federal University of São Paulo

FDA Drug Approvals

Approved Product	Manufacturer	NDC Code	Route	Strength	Effective Date
No FDA approvals found for this drug.

EMA Drug Approvals

Approved Product	Authorization Holder	Status	Issued Date
No EMA approvals found for this drug.

HSA Drug Approvals

Approved Product	Manufacturer	Approval Number	Dosage Form	Strength	Approval Date
No HSA approvals found for this drug.

NMPA Drug Approvals

Approved Product	Company	Approval Number	Drug Type	Dosage Form	Approval Date
No NMPA approvals found for this drug.

PPB Drug Approvals

Approved Product	Registration No.	Company	Licence No.	Strength	Registration Date
No PPB approvals found for this drug.

TGA Drug Approvals

Approved Product	ARTG ID	Sponsor	Registration Type	Status	Registration Date
METARAMINOL TORBAY metaraminol (as tartrate) 5 mg/10 mL injection ampoule	308810	Clinect Pty Ltd	Medicine	A	11/15/2019
METARAMINOL MYX metaraminol (as tartrate) 10 mg/1 mL solution for injection ampoule	310904	Mayne Pharma International Pty Ltd	Medicine	A	2/14/2020
METARAMINOL PHEBRA metaraminol (as tartrate) 3mg/6mL injection vial	264253	Phebra Pty Ltd	Medicine	A	11/30/2016
APO-Metaraminol metaraminol (as tartrate) 5 mg/10 mL solution for injection ampoule	309265	Arrotex Pharmaceuticals Pty Ltd	Medicine	A	9/26/2019
Metaraminol ARX metaraminol (as tartrate) 5 mg/10 mL solution for injection ampoule	309267	Arrotex Pharmaceuticals Pty Ltd	Medicine	A	9/26/2019
METARAMINOL GH PHARMA metaraminol (as tartrate) 3 mg/6 mL solution for injection, vial	300197	Global Harvest Pharmaceuticals Pty Ltd	Medicine	A	6/7/2019
METARAMINOL TORBAY metaraminol (as tartrate) 2.5 mg/5 mL injection ampoule	308807	Clinect Pty Ltd	Medicine	A	11/15/2019
METARAMINOL GH PHARMA metaraminol (as tartrate) 5 mg/10 mL solution for injection, vial	304084	Global Harvest Pharmaceuticals Pty Ltd	Medicine	A	6/7/2019
METARAMINOL TORBAY metaraminol (as tartrate)10 mg/1 mL injection ampoule	308808	Clinect Pty Ltd	Medicine	A	11/15/2019
ARAMINE metaraminol (as tartrate) 10 mg/1 mL injection vial	284785	Phebra Pty Ltd	Medicine	A	1/16/2018

Health Canada Drug Approvals

Approved Product	Company	DIN	Dosage Form	Strength	Market Date
No Health Canada approvals found for this drug.

CIMA AEMPS Drug Approvals

Approved Product	Company	Registration Number	Pharmaceutical Form	Prescription Type	Status
No CIMA AEMPS (Spain) approvals found for this drug.

Philippines FDA Drug Approvals

Approved Product	Company	License Number	Dosage Form	Strength	Approval Date
No Philippines FDA approvals found for this drug.

Saudi SFDA Drug Approvals

Approved Product	Company	License Number	Dosage Form	Strength	Approval Date
No Saudi SFDA approvals found for this drug.

Malaysia NPRA Drug Approvals

Approved Product	Company	Registration Number	Dosage Form	Strength	Approval Date
No Malaysia NPRA approvals found for this drug.

UK EMC Drug Information

Medicine Name	MA Holder	MA Number	Pharmaceutical Form	Active Ingredient	Authorization Date
No UK EMC drug information found for this drug.

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