Ketamine

Generic Name: Ketamine

Brand Names: Ketalar

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₆ClNO

CAS Number: 6740-88-1

Unique Ingredient Identifier: 690G0D6V8H

Background: Ketamine is an NMDA receptor antagonist with a potent anesthetic effect. It was developed in 1963 as a replacement for phencyclidine (PCP) by Calvin Stevens at Parke Davis Laboratories. It started being used for veterinary purposes in Belgium and in 1964 was proven that compared to PCP, it produced minor hallucinogenic effects and shorter psychotomimetic eff...

Indication: Ketamine is indicated as an anesthetic agent for recommended diagnostic and surgical procedures. If skeletal muscle relaxation is needed, it should be combined with a muscle relaxant. If the surgical procedure involves visceral pain, it should be supplemented with an agent that obtunds visceral pain. Ketamine can be used for induction of anesthesia prior oth...

Associated Conditions: -

Associated Therapies: General Anesthesia, Induction and Maintenance of General Anesthesia

Clinical Trials

Early Effects of Ketamine vs Placebo With Venlafaxine in Severe Depression Patients

Phase 3

Recruiting

Conditions: Major Depressive Episode

Interventions: Drug: Placebo
Drug: Ketamine

First Posted Date: 2024-07-18

Last Posted Date: 2024-12-19

Lead Sponsor: Assistance Publique - Hôpitaux de Paris

Target Recruit Count: 60

Registration Number: NCT06508710

Locations: 🇫🇷
Psychiatry unit, Le Kremlin Bicêtre, France
🇫🇷
Bicetre Hospital - CRC, Le Kremlin-Bicêtre, France
🇫🇷
CEA/SHFJ, Orsay, France

and more 1 locations

Low-Dose Ketamine Infusion During Burn Wound Care

Phase 4

Recruiting

Conditions: Burn
Pain
Dissociation
Opioid

Interventions: Drug: Ketamine
Drug: 0.9% NaCl

First Posted Date: 2024-07-17

Last Posted Date: 2024-12-13

Lead Sponsor: University of Tennessee

Target Recruit Count: 140

Registration Number: NCT06506565

Locations: 🇺🇸
Regional One Health, Memphis, Tennessee, United States

Intraoperative Subanesthetic Ketamine Versus Dexmedetomidine Infusion for Prevention of Post-traumatic Stress Disorder After Traumatic Brain Surgeries

Not Applicable

Conditions: Subanesthetic Ketamine Dexmedetomidin

Interventions: Drug: ketamine
Drug: dexmedetomidine

First Posted Date: 2024-07-12

Last Posted Date: 2024-08-19

Lead Sponsor: Zagazig University

Target Recruit Count: 52

Registration Number: NCT06498700

Locations: 🇪🇬
Faculty of Medicine,Zagazig University, Zagazig, El Sharkia, Egypt

Effects of Dexmedetomidine Versus Ketamine on Inflammatory Response and Hemodynamic in Patients

Phase 1

Recruiting

Conditions: Haemodynamic Rebound

Interventions: Drug: Dexmedetomidine
Drug: Ketamine

First Posted Date: 2024-07-08

Last Posted Date: 2024-11-27

Lead Sponsor: New Valley University

Target Recruit Count: 2

Registration Number: NCT06490731

Locations: 🇪🇬
asyut University, Asyut, Egypt

Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant Depression

Phase 1

Recruiting

Conditions: Healthy
Major Depressive Disorder
Treatment Resistant Depression

Interventions: Drug: Ketamine
Other: Saline

First Posted Date: 2024-06-28

Last Posted Date: 2024-06-28

Lead Sponsor: Baylor College of Medicine

Target Recruit Count: 100

Registration Number: NCT06480201

Locations: 🇺🇸
Wells Medicine, Houston, Texas, United States
🇺🇸
Baylor College of Medicine Jamail Specialty Care Center, Houston, Texas, United States

Effect of Ketalar or Dexmedetomidine on Increased Sensitivity to Pain Following Treatment With Remifentanil

Not Applicable

Recruiting

Conditions: Cholecystectomy

Interventions: Drug: Ketalar
Drug: Dexmedetomidine

First Posted Date: 2024-06-25

Last Posted Date: 2024-08-07

Lead Sponsor: Assaf-Harofeh Medical Center

Target Recruit Count: 90

Registration Number: NCT06473896

Locations: 🇮🇱
Shamir (Asaf Harofe) Medical Center, Be'er Ya'aqov, Israel

Postoperative Pain Protocol Limiting Narcotics for Laparoscopic Hand-assisted Donor Nephrectomy

Not Applicable

Terminated

Conditions: Narcotic Use
Renal Transplant Donor of Left Kidney

Interventions: Other: Placebo
Drug: Ketamine

First Posted Date: 2024-06-14

Last Posted Date: 2024-06-14

Lead Sponsor: Stony Brook University

Target Recruit Count: 56

Registration Number: NCT06458842

The Effect of Outpatient Ketamine Infusion on Chronic Neuropathic Pain and PTSD

Phase 4

Not yet recruiting

Conditions: Neuropathic Pain
PTSD

Interventions: Drug: Ketamine + Magnesium sulfate
Drug: Ketamine
Drug: Magnesium sulfate

First Posted Date: 2024-05-16

Last Posted Date: 2024-08-06

Lead Sponsor: Margaux M. Salas, PhD

Target Recruit Count: 30

Registration Number: NCT06414356

Propofol-ketamine or Propofol-fentanyl for Procedural Sedation in the Short-term Gynecological Case

Not Applicable

Completed

Conditions: Ketamine
Sedation
Gynecologic Disease

Interventions: Drug: Ketamine
Drug: Fentanyl

First Posted Date: 2024-05-14

Last Posted Date: 2024-08-20

Lead Sponsor: Ondokuz Mayıs University

Target Recruit Count: 60

Registration Number: NCT06412861

Locations: 🇹🇷
Ondokuz Mayıs University Faculty of Medicine, Samsun, Turkey

Pharmacologic Treatment Augmentation in Chronic Depression

Phase 2

Not yet recruiting

Conditions: Major Depressive Disorder

Interventions: Drug: Placebo
Drug: Ketamine
Behavioral: TAU
Behavioral: CBASP

First Posted Date: 2024-05-13

Last Posted Date: 2024-05-13

Lead Sponsor: University Hospital Tuebingen

Target Recruit Count: 60

Registration Number: NCT06410599

Locations: 🇩🇪
Universitätsklinikum Jena - Klinik für Psychiatrie und Psychotherapie, Jena, Thüringen, Germany
🇩🇪
Universitätsklinikum Tübingen - Klinik für Psychiatrie und Psychotherapie, Tübingen, Baden-Würtemberg, Germany

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