Ketamine

Generic Name
Ketamine
Brand Names
Ketalar
Drug Type
Small Molecule
Chemical Formula
C13H16ClNO
CAS Number
6740-88-1
Unique Ingredient Identifier
690G0D6V8H
Background

Ketamine is an NMDA receptor antagonist with a potent anesthetic effect. It was developed in 1963 as a replacement for phencyclidine (PCP) by Calvin Stevens at Parke Davis Laboratories. It started being used for veterinary purposes in Belgium and in 1964 was proven that compared to PCP, it produced minor hallucinogenic effects and shorter psychotomimetic eff...

Indication

Ketamine is indicated as an anesthetic agent for recommended diagnostic and surgical procedures. If skeletal muscle relaxation is needed, it should be combined with a muscle relaxant. If the surgical procedure involves visceral pain, it should be supplemented with an agent that obtunds visceral pain. Ketamine can be used for induction of anesthesia prior oth...

Associated Conditions
-
Associated Therapies
General Anesthesia, Induction and Maintenance of General Anesthesia

Ketamine as a Supplement to Local Anesthesia for Minor Procedures

First Posted Date
2024-02-29
Last Posted Date
2024-03-15
Lead Sponsor
Loyola University
Target Recruit Count
108
Registration Number
NCT06284473
Locations
🇺🇸

Loyola University Medical Center, Maywood, Illinois, United States

Ketamine Versus Propofol as ICU Sedation

First Posted Date
2024-02-06
Last Posted Date
2024-02-06
Lead Sponsor
Menoufia University
Target Recruit Count
100
Registration Number
NCT06243822
Locations
🇪🇬

Menoufia University, Shibīn Al Kawm, Menoufia, Egypt

Ketamine for Veterans With Parkinson's Disease

Phase 2
Not yet recruiting
Conditions
Interventions
First Posted Date
2024-01-30
Last Posted Date
2024-08-12
Lead Sponsor
VA Office of Research and Development
Target Recruit Count
80
Registration Number
NCT06231563
Locations
🇺🇸

San Francisco VA Medical Center, San Francisco, CA, San Francisco, California, United States

Neural Circuit Effects of Ketamine in Depression

Phase 4
Recruiting
Conditions
Interventions
First Posted Date
2024-01-19
Last Posted Date
2024-02-15
Lead Sponsor
Icahn School of Medicine at Mount Sinai
Target Recruit Count
120
Registration Number
NCT06213324
Locations
🇺🇸

Icahn School of Medicine at Mount Sinai, New York, New York, United States

Dexmedetomidine-ketamine Combination Versus Fentanyl-midazolam During Bronchoscopy

First Posted Date
2023-12-29
Last Posted Date
2023-12-29
Lead Sponsor
University of Patras
Target Recruit Count
50
Registration Number
NCT06185127
Locations
🇬🇷

Naval Hospital, Athens, Attica, Greece

Use of Ketamine for Conscious Sedation in Flexible Bronchoscopy

First Posted Date
2023-12-26
Last Posted Date
2023-12-26
Lead Sponsor
Brooke Army Medical Center
Target Recruit Count
66
Registration Number
NCT06181188
Locations
🇺🇸

Brooke Army Medical Center, San Antonio, Texas, United States

Effect of Ketamine and Etomidate During RSI on Long Term Outcomes

First Posted Date
2023-12-22
Last Posted Date
2023-12-22
Lead Sponsor
Vanderbilt University Medical Center
Target Recruit Count
1756
Registration Number
NCT06179485
Locations
🇺🇸

Vanderbilt University Medical Center, Nashville, Tennessee, United States

Effect of Ketamine on Intraoperative Motor Evoked Potentials

Phase 3
Recruiting
Conditions
Interventions
First Posted Date
2023-11-21
Last Posted Date
2024-02-12
Lead Sponsor
University of California, San Francisco
Target Recruit Count
20
Registration Number
NCT06140927
Locations
🇺🇸

University of California, San Francisco, San Francisco, California, United States

Intranasal Ketamine Effectiveness in Reducing Intramuscular Injection Pain Before Sedation Among Children

Phase 4
Completed
Conditions
Interventions
First Posted Date
2023-11-18
Last Posted Date
2024-06-04
Lead Sponsor
Tehran University of Medical Sciences
Target Recruit Count
84
Registration Number
NCT06139380
Locations
🇮🇷

IKHC, Tehran, Iran, Islamic Republic of

Ketamine and Neurofeedback-Training: Effects on Neuroplasticity in Cocaine Addiction

First Posted Date
2023-11-09
Last Posted Date
2024-12-20
Lead Sponsor
Dr. med. Marcus Herdener
Target Recruit Count
120
Registration Number
NCT06125054
Locations
🇨🇭

Psychiatric University Hospital Zurich, University of Zurich, Zürich, Switzerland

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