Estradiol
- Generic Name
- Estradiol
- Brand Names
- Activella 1/0.5 28 Day, Activelle, Amabelz 0.5/0.1 28 Day, Angeliq 0.25/0.5 28 Day, Bijuva, Climara, Climara Pro, Combipatch, Divigel, Dotti, Elestrin, Estalis, Estrace, Estradot, Estring, Estrogel, Etyqa 0.5/0.1 28 Day, Evamist, Imvexxy 4 Mcg Starter Pack, Lopreeza 1/0.5 28 Day, Lyllana, Menostar, Mimvey, Minivelle, Myfembree, Oesclim, Oriahnn 28 Day Kit, Prefest 30 Day, Vagifem, Vivelle, Yuvafem
- Drug Type
- Small Molecule
- Chemical Formula
- C18H24O2
- CAS Number
- 50-28-2
- Unique Ingredient Identifier
- 4TI98Z838E
- Background
Estradiol is a naturally occurring hormone circulating endogenously in females. It is commercially available in several hormone therapy products for managing conditions associated with reduced estrogen, such as vulvovaginal atrophy and hot flashes. Some available forms of estradiol include oral tablets, injections, vaginal rings, transdermal patches, sprays,...
- Indication
Estradiol is indicated in various preparations for the treatment of moderate to severe vasomotor symptoms and vulvar and vaginal atrophy due to menopause, for the treatment of hypoestrogenism due to hypogonadism, castration, or primary ovarian failure, and for the prevention of postmenopausal osteoporosis. It is also used for the treatment of breast cancer (...
- Associated Conditions
- Atrophic Vaginitis, Breast Cancer, Breast engorgement caused by Postpartum state, Heavy Menstrual Bleeding, Hypogonadism female, Kraurosis Vulvae, Metastatic Breast Cancer, Osteoporosis, Postmenopausal Osteoporosis, Premature Ovarian Failure (POF), Prostate Cancer, Severe Pain, Urogenital atrophy, Vasomotor Symptoms Associated With Menopause, Vulvo Vaginal Atrophy, Advanced androgen dependent Prostate cancer, Female castration, Hypoestrogenism
- Associated Therapies
- Contraception, Hormone Replacement Therapy, Palliative Treatment
Cross-sex Hormone Therapy and Neuronal Plasticity
- First Posted Date
- 2018-08-29
- Last Posted Date
- 2018-08-29
- Lead Sponsor
- Hospital de Clinicas de Porto Alegre
- Target Recruit Count
- 30
- Registration Number
- NCT03651427
- Locations
- 🇧🇷
Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande Do Sul, Brazil
Study to Investigate the Pharmacokinetics & Safety Following One Application of 3 Different Doses 0.5,0.75,& 1.25 gm,a Transdermal Estradiol Cream (VML-0203), in Comparison to a Single Dose of EstroGel 1.25 gm to Healthy Post-menopausal Women.
- First Posted Date
- 2018-06-14
- Last Posted Date
- 2022-04-27
- Lead Sponsor
- Viramal Limited
- Target Recruit Count
- 20
- Registration Number
- NCT03556800
- Locations
- 🇬🇧
Simbec Research Ltd, Merthyr Tydfil, Wales, United Kingdom
Endometrial Preparation in Frozen Embryo Transfer Cycles
- First Posted Date
- 2018-05-30
- Last Posted Date
- 2018-05-30
- Lead Sponsor
- Meir Medical Center
- Target Recruit Count
- 100
- Registration Number
- NCT03540979
Vaginal Estrogen on Postpartum Atrophy, Perineal Pain, and Sexual Function
- First Posted Date
- 2018-04-10
- Last Posted Date
- 2021-12-22
- Lead Sponsor
- Ohio State University
- Target Recruit Count
- 59
- Registration Number
- NCT03493126
- Locations
- 🇺🇸
The Ohio State University Urogynecology Clinic, Columbus, Ohio, United States
Estradiol Pretreatment With Misoprostol in Second Trimester Miscarriage
- Conditions
- Interventions
- First Posted Date
- 2018-03-27
- Last Posted Date
- 2019-01-29
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 200
- Registration Number
- NCT03479879
- Locations
- 🇪🇬
Ain Shams University Maternity Hospital, Cairo, Egypt
Study to Assess Potential Impairments in Estradiol Augmentation of Gonadotropin Secretion in Polycystic Ovary Syndrome
- First Posted Date
- 2018-01-17
- Last Posted Date
- 2023-11-02
- Lead Sponsor
- University of Virginia
- Target Recruit Count
- 37
- Registration Number
- NCT03401047
- Locations
- 🇺🇸
University of Virginia Clinical Research Unit, Charlottesville, Virginia, United States
Study to Evaluate Estradiol Vaginal Tablets vs Promestriene Vaginal Cream
- First Posted Date
- 2017-12-28
- Last Posted Date
- 2021-02-11
- Lead Sponsor
- Instituto Palacios
- Target Recruit Count
- 120
- Registration Number
- NCT03385551
- Locations
- 🇮🇹
IRCCS "S Matteo Foundation", Pavia, Italy
🇪🇸Instituto Palacios, Madrid, Spain
The Temporo-spatial Dynamics of Genital Tract Microbiota
- First Posted Date
- 2017-12-06
- Last Posted Date
- 2021-02-09
- Lead Sponsor
- Peter Humaidan
- Target Recruit Count
- 27
- Registration Number
- NCT03363828
- Locations
- 🇩🇰
The Fertility Clinic, Regional Hospital of Skive, Skive, Denmark
🇩🇰The Fertility Clinic Skive, Skive, Denmark
Comparison Between Testosterone and Estradiol Over the Homogenization of Follicular Cohort
- First Posted Date
- 2017-08-03
- Last Posted Date
- 2017-08-03
- Lead Sponsor
- Hospital de Clinicas de Porto Alegre
- Target Recruit Count
- 26
- Registration Number
- NCT03238092
The Effects of 17β-estradiol on Skeletal Muscle
- First Posted Date
- 2017-03-03
- Last Posted Date
- 2018-08-16
- Lead Sponsor
- McMaster University
- Registration Number
- NCT03069781
- Locations
- 🇨🇦
McMaster Univeristy, Hamilton, Ontario, Canada
Drug Development Updates
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