Estradiol

Generic Name: Estradiol

Brand Names: Activella 1/0.5 28 Day, Activelle, Amabelz 0.5/0.1 28 Day, Angeliq 0.25/0.5 28 Day, Bijuva, Climara, Climara Pro, Combipatch, Divigel, Dotti, Elestrin, Estalis, Estrace, Estradot, Estring, Estrogel, Etyqa 0.5/0.1 28 Day, Evamist, Imvexxy 4 Mcg Starter Pack, Lopreeza 1/0.5 28 Day, Lyllana, Menostar, Mimvey, Minivelle, Myfembree, Oesclim, Oriahnn 28 Day Kit, Prefest 30 Day, Vagifem, Vivelle, Yuvafem

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₂₄O_₂

CAS Number: 50-28-2

Unique Ingredient Identifier: 4TI98Z838E

Background: Estradiol is a naturally occurring hormone circulating endogenously in females. It is commercially available in several hormone therapy products for managing conditions associated with reduced estrogen, such as vulvovaginal atrophy and hot flashes. Some available forms of estradiol include oral tablets, injections, vaginal rings, transdermal patches, sprays,...

Indication: Estradiol is indicated in various preparations for the treatment of moderate to severe vasomotor symptoms and vulvar and vaginal atrophy due to menopause, for the treatment of hypoestrogenism due to hypogonadism, castration, or primary ovarian failure, and for the prevention of postmenopausal osteoporosis. It is also used for the treatment of breast cancer (...

Associated Conditions: Atrophic Vaginitis, Breast Cancer, Breast engorgement caused by Postpartum state, Heavy Menstrual Bleeding, Hypogonadism female, Kraurosis Vulvae, Metastatic Breast Cancer, Osteoporosis, Postmenopausal Osteoporosis, Premature Ovarian Failure (POF), Prostate Cancer, Severe Pain, Urogenital atrophy, Vasomotor Symptoms Associated With Menopause, Vulvo Vaginal Atrophy, Advanced androgen dependent Prostate cancer, Female castration, Hypoestrogenism

Associated Therapies: Contraception, Hormone Replacement Therapy, Palliative Treatment

Clinical Trials

Estrogen Therapy as Prevention in the Progression of Aneurysm (EPPA) Trial

Phase 2

Withdrawn

Conditions: Cerebral Aneurysm
Menopause
Treatment

Interventions: Drug: Placebo
Drug: Estradiol

First Posted Date: 2013-07-11

Last Posted Date: 2021-01-05

Lead Sponsor: Rush University Medical Center

Registration Number: NCT01895881

Locations: 🇺🇸
Rush University Medical Center, Chicago, Illinois, United States

Efficacy and Safety Of Spil's Estradiol Vaginal Tablet

Phase 3

Terminated

Conditions: Vulvar Atrophy
Vaginal Atrophy

Interventions: Drug: Estradiol

First Posted Date: 2012-12-20

Last Posted Date: 2018-10-09

Lead Sponsor: Sun Pharmaceutical Industries Limited

Target Recruit Count: 49

Registration Number: NCT01753102

Locations: 🇮🇳
Biniwale Clinic Pvt. Ltd,, Pune, Maharashtra, India

Estradiol vs Lysteda in Treatment of Heavy Menstrual Bleeding

Not Applicable

Conditions: Menstrual Cycle and Uterine Bleeding Disorders

Interventions: Drug: Lysteda
Drug: Estradiol

First Posted Date: 2012-08-07

Last Posted Date: 2015-02-16

Lead Sponsor: Kay I Waud MD PhD

Target Recruit Count: 100

Registration Number: NCT01659008

Locations: 🇺🇸
Sentara Norfolk General Emergency Department, Norfolk, Virginia, United States
🇺🇸
Jones Institue Clinical Research Center, Norfolk, Virginia, United States

Mirena and Estrogen for Control of Perimenopause Symptoms and Ovulation Suppression

Not Applicable

Completed

Conditions: Menopausal and Other Perimenopausal Disorders

Interventions: Drug: Mirena
Drug: Placebo Gel
Drug: Estradiol

First Posted Date: 2012-06-06

Last Posted Date: 2015-12-02

Lead Sponsor: University of Colorado, Denver

Target Recruit Count: 39

Registration Number: NCT01613131

Locations: 🇺🇸
University of Colorado, Aurora, Colorado, United States

Timing Estrogen After MenoPaUSe

Not Applicable

Completed

Conditions: Insulin Resistance

Interventions: Drug: Estradiol

First Posted Date: 2012-05-24

Last Posted Date: 2021-03-01

Lead Sponsor: University of Colorado, Denver

Target Recruit Count: 53

Registration Number: NCT01605071

Locations: 🇺🇸
University of Colorado Denver, Aurora, Colorado, United States

Postmenopausal Facial Skin After Estradiol and Genistein Topical Treatment

Phase 2

Completed

Conditions: Atrophy

Interventions: Drug: Estradiol
Drug: isoflavone

First Posted Date: 2012-03-14

Last Posted Date: 2012-03-14

Lead Sponsor: Federal University of São Paulo

Target Recruit Count: 30

Registration Number: NCT01553773

Locations: 🇧🇷
Department of Gynecology - UNIFESP, Sao Paulo, Brazil

Relationship Between the Menstrual Cycle and Heart Disease in Women

Not Applicable

Completed

Conditions: Coronary Heart Disease

Interventions: Drug: Ethinyl Estradiol-Levonorgestrel combination
Drug: leuprolide acetate
Drug: Estradiol
Drug: Progesterone

First Posted Date: 2012-03-07

Last Posted Date: 2017-03-22

Lead Sponsor: Oregon Health and Science University

Target Recruit Count: 5

Registration Number: NCT01546454

Locations: 🇺🇸
Oregon Health & Sciences University, Department of Obstetrics and Gynecology, Women's Health Research Unit, Portland, Oregon, United States