Estradiol

Generic Name: Estradiol

Brand Names: Activella 1/0.5 28 Day, Activelle, Amabelz 0.5/0.1 28 Day, Angeliq 0.25/0.5 28 Day, Bijuva, Climara, Climara Pro, Combipatch, Divigel, Dotti, Elestrin, Estalis, Estrace, Estradot, Estring, Estrogel, Etyqa 0.5/0.1 28 Day, Evamist, Imvexxy 4 Mcg Starter Pack, Lopreeza 1/0.5 28 Day, Lyllana, Menostar, Mimvey, Minivelle, Myfembree, Oesclim, Oriahnn 28 Day Kit, Prefest 30 Day, Vagifem, Vivelle, Yuvafem

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₂₄O_₂

CAS Number: 50-28-2

Unique Ingredient Identifier: 4TI98Z838E

Background: Estradiol is a naturally occurring hormone circulating endogenously in females. It is commercially available in several hormone therapy products for managing conditions associated with reduced estrogen, such as vulvovaginal atrophy and hot flashes. Some available forms of estradiol include oral tablets, injections, vaginal rings, transdermal patches, sprays,...

Indication: Estradiol is indicated in various preparations for the treatment of moderate to severe vasomotor symptoms and vulvar and vaginal atrophy due to menopause, for the treatment of hypoestrogenism due to hypogonadism, castration, or primary ovarian failure, and for the prevention of postmenopausal osteoporosis. It is also used for the treatment of breast cancer (...

Associated Conditions: Atrophic Vaginitis, Breast Cancer, Breast engorgement caused by Postpartum state, Heavy Menstrual Bleeding, Hypogonadism female, Kraurosis Vulvae, Metastatic Breast Cancer, Osteoporosis, Postmenopausal Osteoporosis, Premature Ovarian Failure (POF), Prostate Cancer, Severe Pain, Urogenital atrophy, Vasomotor Symptoms Associated With Menopause, Vulvo Vaginal Atrophy, Advanced androgen dependent Prostate cancer, Female castration, Hypoestrogenism

Associated Therapies: Contraception, Hormone Replacement Therapy, Palliative Treatment

Clinical Trials

Sex Steroids and the Serotonin Transporter

Phase 4

Completed

Conditions: Transsexualism

Interventions: Drug: Testolactone undecanoate
Drug: Cyproterone Acetate
Drug: Estradiol
Drug: Lynestrenol
Drug: 5-alpha reductase inhibitor

First Posted Date: 2010-02-09

Last Posted Date: 2014-01-03

Lead Sponsor: Medical University of Vienna

Target Recruit Count: 32

Registration Number: NCT01065220

Locations: 🇦🇹
Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria

Research Investigation of Soy and Estrogen

Phase 2

Completed

Conditions: Menopause
Hot Flashes

Interventions: Dietary Supplement: Soy Phytoestrogen
Drug: Estradiol
Drug: Medroxyprogesterone Acetate (MPA)
Drug: MPA Placebo
Drug: Soy Placebo

First Posted Date: 2009-10-19

Last Posted Date: 2020-12-07

Lead Sponsor: University of Illinois at Chicago

Target Recruit Count: 96

Registration Number: NCT00997893

Locations: 🇺🇸
University of Illinois at Chicago, Chicago, Illinois, United States

The Effects of Isoflavone and Estrogen in Sex Response in Climacteric Women

Phase 3

Conditions: Postmenopausal Symptoms

Interventions: Drug: isoflavone
Drug: Placebo
Drug: estradiol

First Posted Date: 2009-05-20

Last Posted Date: 2009-05-20

Lead Sponsor: Federal University of São Paulo

Target Recruit Count: 60

Registration Number: NCT00905723

Locations: 🇧🇷
Ambulatório de Ginecologia Endócrina, São Paulo, Brazil

Reciprocal Influence of Sex Steroid Environment and Adipocyte Function in Men

Phase 1

Completed

Conditions: Healthy

Interventions: Drug: Aromatase inhibition
Drug: Estradiol

First Posted Date: 2008-08-22

Last Posted Date: 2011-08-30

Lead Sponsor: University Hospital, Ghent

Target Recruit Count: 20

Registration Number: NCT00740194

Locations: 🇧🇪
University Hospital Ghent, Ghent, Belgium

Study to Evaluate Divigel for the Treatment of Postmenoupausal Symptoms

Phase 3

Completed

Conditions: Postmenopausal Symptoms

First Posted Date: 2008-08-01

Last Posted Date: 2008-09-26

Lead Sponsor: Upsher-Smith Laboratories

Target Recruit Count: 495

Registration Number: NCT00727129

Vaginal Testosterone Cream vs ESTRING for Vaginal Dryness or Decreased Libido in Early Stage Breast Cancer Patients

Phase 2

Completed

Conditions: Sexual Dysfunction, Physiological

Interventions: Drug: Testosterone Cream
Drug: Estring

First Posted Date: 2008-06-16

Last Posted Date: 2014-06-02

Lead Sponsor: University of California, San Francisco

Target Recruit Count: 76

Registration Number: NCT00698035

Locations: 🇺🇸
UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California, United States

Estrogen in Postmenopausal Women With ER Positive Metastatic Breast Cancer After Failure of Sequential Endocrine Therapy

Phase 2

Terminated

Conditions: Breast Cancer
Neoplasms, Breast
Cancer of the Breast

Interventions: Drug: Estrace
Drug: Anastrozole

First Posted Date: 2008-04-18

Last Posted Date: 2017-04-12

Lead Sponsor: Georgetown University

Target Recruit Count: 11

Registration Number: NCT00661531

Locations: 🇺🇸
Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States
🇺🇸
Cooper Cancer Institute, Voorhees, New Jersey, United States
🇺🇸
Georgetown University Medical Center, Washington, District of Columbia, United States