Lofexidine
- Generic Name
- Lofexidine
- Brand Names
- Lucemyra
- Drug Type
- Small Molecule
- Chemical Formula
- C11H12Cl2N2O
- CAS Number
- 31036-80-3
- Unique Ingredient Identifier
- UI82K0T627
- Background
Lofexidine is a non-opioid centrally acting alpha2-adrenergic receptor agonist that was first approved for the treatment of opioid withdrawal in the United Kingdom in 1992. It was first studied for use as an antihypertensive in 1980, but its researched was stopped as it was found less effective for the treatment of hypertension than clonidine. Lofexidine was...
- Indication
Lofexidine is indicated for mitigation of symptoms associated with acute withdrawal from opioids and for facilitation of the completion of opioid discontinuation treatment. It is the first non-opioid medication for the symptomatic management of opioid discontinuation.
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- Associated Conditions
- Abrupt opioid withdrawal
- Associated Therapies
- -
Evaluation of Lofexidine for Treatment of Opioid Withdrawal - 3
- Conditions
- First Posted Date
- 1999-09-21
- Last Posted Date
- 2017-01-12
- Lead Sponsor
- National Institute on Drug Abuse (NIDA)
- Registration Number
- NCT00000354
- Locations
- 🇺🇸
University of Pennsylvania, Philadelphia, Pennsylvania, United States
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