Vigabatrin
- Generic Name
- Vigabatrin
- Brand Names
- Sabril, Vigadrone, Kigabeq
- Drug Type
- Small Molecule
- Chemical Formula
- C6H11NO2
- CAS Number
- 68506-86-5
- Unique Ingredient Identifier
- GR120KRT6K
- Background
Vigabatrin is an analog of gamma-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the central nervous system, used in the treatment of refractory seizures and infantile spasms. It irreversibly inhibits the enzyme responsible for GABA metabolism, thereby increasing levels of circulating GABA. Although administered as a racemic mixture, only t...
- Indication
Vigabatrin is indicated as adjunctive therapy in the treatment of refractory complex partial seizures in patients 2 years of age and older who have had inadequate responses to multiple previous treatments (i.e. not to be used for first-line therapy). It is also indicated as monotherapy in the treatment of infantile spasms in patients between 1 month and 2 ye...
- Associated Conditions
- Infantile Spasms (IS), Refractory Complex partial seizures
- Associated Therapies
- -
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