Overview
Triheptanoin is a source of heptanoate fatty acids, which can be metabolized without the enzymes of long chain fatty acid oxidation. In clinical trials, patients with long chain fatty acid oxidation disorders (lc-FAODs) treated with triheptanoin are less likely to develop hypoglycemia, cardiomyopathy, rhabdomyolysis, and hepatomegaly. Complications in lc-FAOD patients are reduced from approximately 60% to approximately 10% with the addition of triheptanoin. Triheptanoin was granted FDA approval on 30 June 2020.
Indication
Triheptanoin is a medium chain triglyceride indicated to provide calories and fatty acids to treat long chain fatty acid oxidation disorders (lc-FAODs).
Associated Conditions
- Long-chain Fatty Acid Oxidation Disorders (LC-FAOD)
Clinical Trials
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Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2016/11/21 | N/A | NO_LONGER_AVAILABLE | Jerry Vockley, MD, PhD | ||
2016/11/09 | Phase 3 | Terminated | |||
2016/09/29 | Phase 2 | Completed | Institut National de la Santé Et de la Recherche Médicale, France | ||
2016/05/27 | Early Phase 1 | UNKNOWN | |||
2016/03/02 | Phase 2 | UNKNOWN | Center for Rare Neurological Diseases, Norcross, GA | ||
2016/02/10 | Phase 1 | Completed | |||
2015/11/09 | Phase 2 | Terminated | |||
2015/07/16 | N/A | NO_LONGER_AVAILABLE | Irina A Anselm | ||
2015/05/25 | Phase 2 | Completed | Institut National de la Santé Et de la Recherche Médicale, France | ||
2015/05/04 | Phase 2 | Completed |
FDA Drug Approvals
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HSA Drug Approvals
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NMPA Drug Approvals
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PPB Drug Approvals
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TGA Drug Approvals
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