Vasopressin

Generic Name: Vasopressin

Brand Names: Vasostrict

Drug Type: Small Molecule

Chemical Formula: C_₉₂H_₁₃₀N_₂₈O_₂₄S_₄

CAS Number: 11000-17-2

Unique Ingredient Identifier: Y87Y826H08

Background: Vasopressin (arginine-vasopressin or antidiuretic hormone) is a nonapeptide primarily produced in the hypothalamus that exhibits diverse physiological functions related to diuresis, hemodynamic modulation, and behaviour. Vasopressin is very similar to oxytocin, differing in the third and eighth amino acids. Despite a wide variety of functions, exogenous vaso...

Indication: 1.诊断和治疗由于缺乏抗利尿激素而引起的尿崩症，也用于其他药物效果不佳的腹部肌肉松弛；

2.脑外科手术后或头颅创伤后多尿的初期治疗；

3.用于食管、胃肠道消化道疾病的急性大出血的辅助治疗。

Associated Conditions: Acute Circulatory Failure

Associated Therapies: Dental Local Anesthesia

Clinical Trials

Use of Vasopressin in Patients at High Risk of Acute Kidney Injury Admitted to the ICU

Phase 2

Not yet recruiting

Conditions: Critical Illness

Interventions: Other: 0,9% saline solution
Drug: Vasopressin

First Posted Date: 2024-08-09

Last Posted Date: 2024-08-09

Lead Sponsor: Hospital do Coracao

Target Recruit Count: 60

Registration Number: NCT06547892

Locations: 🇧🇷
Matheus Liguori Feliciano da Silva, São Paulo, SP, Brazil

Vasopressin Hemodynamic Response as a Septic Shock Subphenotype Indicator

Not yet recruiting

Conditions: Shock, Septic

Interventions: Drug: Vasopressin

First Posted Date: 2024-05-23

Last Posted Date: 2024-11-20

Lead Sponsor: The Cleveland Clinic

Target Recruit Count: 48

Registration Number: NCT06426407

Registry of Patients in Shock Treated With Vasopressin

Recruiting

Conditions: Vasopressor Adverse Reaction
Vasopressin Causing Adverse Effects in Therapeutic Use
Shock
Vasopressin Deficiency

First Posted Date: 2024-05-21

Last Posted Date: 2024-07-15

Lead Sponsor: Hospital Universitario 12 de Octubre

Target Recruit Count: 500

Registration Number: NCT06422975

Locations: 🇪🇸
Hospital Universitario de Basurto, Bilbao, Spain
🇪🇸
Hospital Universitario de Cruces, Baracaldo, Spain
🇪🇸
Hospital Lucus Augustus, Lugo, Spain

and more 21 locations

Tranexamic Acid in Vaginal Reconstructive Surgery

Phase 4

Not yet recruiting

Conditions: Pelvic Organ Prolapse

Interventions: Other: NaCl 0.9%
Drug: Tranexamic acid
Drug: Vasopressin

First Posted Date: 2024-05-17

Last Posted Date: 2024-05-17

Lead Sponsor: The University of Texas Medical Branch, Galveston

Target Recruit Count: 36

Registration Number: NCT06419075

Locations: 🇺🇸
University of Texas Medical Branch Galveston, Galveston, Texas, United States

Oral Vasopressin Modulates Neural Responses to Looming Visual Stimuli: An Eye-tracking Study

Not Applicable

Recruiting

Conditions: Healthy

Interventions: Drug: Placebo
Drug: Vasopressin

First Posted Date: 2024-03-25

Last Posted Date: 2024-04-11

Lead Sponsor: University of Electronic Science and Technology of China

Target Recruit Count: 80

Registration Number: NCT06329063

Locations: 🇨🇳
University of Electronic Science and Technology of China, Chendu, Sichuan, China

The Effects of Oral Vasopressin on Attention Control: An Eye-tracking Study

Not Applicable

Recruiting

Conditions: Healthy

Interventions: Drug: Placebo
Drug: Vasopressin

First Posted Date: 2024-03-25

Last Posted Date: 2024-04-11

Lead Sponsor: University of Electronic Science and Technology of China

Target Recruit Count: 80

Registration Number: NCT06329037

Locations: 🇨🇳
University of Electronic Science and Technology of China, Chengdu, Sichuan, China

Vasopressin Versus Tranexamic Acid for Control of Blood Loss Related to Abdominal Hysterectomy

Phase 4

Not yet recruiting

Conditions: Uterine Surgery

Interventions: Other: Saline
Drug: Vasopressin
Drug: Tranexamic acid

First Posted Date: 2024-03-04

Last Posted Date: 2024-03-06

Lead Sponsor: Al-Azhar University

Target Recruit Count: 387

Registration Number: NCT06290596

The Effect of Vasopressor Therapy on Renal Perfusion in Septic Shock

Not Applicable

Not yet recruiting

Conditions: Septic Shock
Acute Kidney Injury

Interventions: Drug: Vasopressin
Drug: Angiotensin II
Drug: Norepinephrine

First Posted Date: 2024-01-31

Last Posted Date: 2024-01-31

Lead Sponsor: King's College Hospital NHS Trust

Target Recruit Count: 45

Registration Number: NCT06234592

Locations: 🇬🇧
King's College Hospital, London, United Kingdom

Vasopressin for Septic Shock Pragmatic Trial

Phase 4

Conditions: Septic Shock

Interventions: Drug: Vasopressin
Other: Recommendation to use a lower initiation threshold for vasopressin
Other: Recommendation to use a higher initiation threshold for vasopressin

First Posted Date: 2024-01-22

Last Posted Date: 2024-02-07

Lead Sponsor: Intermountain Health Care, Inc.

Target Recruit Count: 2050

Registration Number: NCT06217562

Locations: 🇺🇸
Utah Valley Hospital, Provo, Utah, United States
🇺🇸
Park City Hospital, Park City, Utah, United States
🇺🇸
St. George Regional Hospital, Saint George, Utah, United States

and more 10 locations

CAlcium and VAsopressin Following Injury Early Resuscitation (CAVALIER) Trial

Phase 2

Recruiting

Conditions: Trauma
Hemorrhage

Interventions: Drug: Calcium Gluconate
Drug: saline placebo
Drug: Vasopressin

First Posted Date: 2023-07-24

Last Posted Date: 2024-12-13

Lead Sponsor: Jason Sperry

Target Recruit Count: 1050

Registration Number: NCT05958342

Locations: 🇺🇸
University of Pittsburgh, Pittsburgh, Pennsylvania, United States

Drug Development Updates

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