Fondaparinux
- Generic Name
- Fondaparinux
- Brand Names
- Arixtra
- Drug Type
- Small Molecule
- Chemical Formula
- C31H53N3O49S8
- CAS Number
- 104993-28-4
- Unique Ingredient Identifier
- J177FOW5JL
- Background
Fondaparinux (Arixtra) is a synthetic anticoagulant agent consisting of five monomeric sugar units and a O-methyl group at the reducing end of the molecule. It is structurally similar to polymeric glycosaminoglycan heparin and heparan sulfate (HS) when they are cleaved into monomeric units. The monomeric sequence in heparin and HS is thought to form the high...
- Indication
Approved for: (1) prophylaxis of VTE for up to one month post surgery in patients undergoing orthopedic surgery of the lower limbs such as hip fracture, hip replacement and knee surgery; (2) prophylaxis of VTE patients undergoing abdominal surgery who are at high risk of thromboembolic complications (e.g. patients undergoing abdominal cancer surgery); (3) tr...
- Associated Conditions
- Acute Pulmonary Embolism (PE), Deep Vein Thrombosis, Non ST Segment Elevation Myocardial Infarction (NSTEMI), ST Segment Elevation Myocardial Infarction (STEMI), Unstable Angina Pectoris, Acute, superficial, symptomatic Vein Thrombosis
- Associated Therapies
- -
Treatment with Aspirin Alone Versus Aspirin in Combination with Fondaparinux Before Early Coronary Assessment in Patients with Non-ST-Elevation Myocardial Infarction
- Conditions
- Interventions
- First Posted Date
- 2024-11-28
- Last Posted Date
- 2024-11-28
- Lead Sponsor
- University of Aarhus
- Target Recruit Count
- 5068
- Registration Number
- NCT06710184
- Locations
- 🇩🇰
Aarhus University Hospital, Department of Cardiology, Aarhus N, Denmark
Endovenous Laser Ablation in Acute Thrombophlebitis of the Varicose Great Saphenous Vein
- Conditions
- Interventions
- First Posted Date
- 2021-08-12
- Last Posted Date
- 2023-12-20
- Target Recruit Count
- 105
- Registration Number
- NCT05001776
- Locations
- 🇷🇺
National Medical Research Center for Therapy and Preventive Medicinel, Moscow, Russian Federation
Enhanced Platelet Inhibition in Critically Ill Patients With COVID-19
- First Posted Date
- 2020-04-29
- Last Posted Date
- 2020-04-29
- Lead Sponsor
- University of Milan
- Target Recruit Count
- 5
- Registration Number
- NCT04368377
- Locations
- 🇮🇹
L. Sacco Hospital, Milano, Lombardia, Italy
Direct Oral Anticoagulants (DOACs) Versus LMWH +/- Warfarin for VTE in Cancer
- First Posted Date
- 2016-04-20
- Last Posted Date
- 2023-10-03
- Lead Sponsor
- Alliance Foundation Trials, LLC.
- Target Recruit Count
- 811
- Registration Number
- NCT02744092
- Locations
- 🇺🇸
Washington Hospital, Fremont, California, United States
🇺🇸Memorial Cancer Institute at Memorial Regional Hospital, Hollywood, Florida, United States
🇺🇸Saint Joseph's Medical Center, Stockton, California, United States
Safety and Pharmacokinetics Study of DU-176b Administered to Patients With Severe Renal Impairment Undergoing Orthopedic Surgery of The Lower Limbs
- Conditions
- Interventions
- First Posted Date
- 2013-05-20
- Last Posted Date
- 2019-03-05
- Lead Sponsor
- Daiichi Sankyo Co., Ltd.
- Target Recruit Count
- 80
- Registration Number
- NCT01857583
- Locations
- 🇯🇵
Toyooka Chuo Hospital, Asahikawa, Hokkaido Prefecture, Japan
Thromboprophylaxis of Venous Thromboembolism in Acutely-ill Medical Inpatients With Thrombocytopenia
- First Posted Date
- 2012-11-16
- Last Posted Date
- 2021-07-21
- Lead Sponsor
- G. d'Annunzio University
- Target Recruit Count
- 7
- Registration Number
- NCT01727401
- Locations
- 🇮🇹
Marcello Di Nisio, Chieti, Italy
ARIXTRA® Adherence in SVT Patients.
- First Posted Date
- 2012-09-24
- Last Posted Date
- 2015-03-27
- Lead Sponsor
- GlaxoSmithKline
- Target Recruit Count
- 1
- Registration Number
- NCT01691495
Superficial Vein Thrombosis (SVT) Treated With Rivaroxaban Versus Fondaparinux
- Conditions
- Interventions
- First Posted Date
- 2011-12-26
- Last Posted Date
- 2023-05-15
- Lead Sponsor
- GWT-TUD GmbH
- Target Recruit Count
- 472
- Registration Number
- NCT01499953
- Locations
- 🇩🇪
Universitätsklinikum Dresden, Dresden, Sachsen, Germany
🇩🇪MVZ Ramdohr, Praxis für Cardiovaskulär- u. Ultraschalldiagnostik, Berlin, Germany
🇩🇪Franziskus-Krankenhaus Berlin, Berlin, Germany
Fondaparinux in Critically Ill Patients With Renal Failure
- First Posted Date
- 2011-11-08
- Last Posted Date
- 2015-06-19
- Lead Sponsor
- Wayne State University
- Target Recruit Count
- 32
- Registration Number
- NCT01467583
- Locations
- 🇺🇸
Detroit Medical Center, Detroit, Michigan, United States
Comparative Analysis of Injectable Anticoagulants for Thromboprophylaxis Post Cancer-related Surgery
- Conditions
- Interventions
- First Posted Date
- 2011-10-03
- Last Posted Date
- 2017-05-16
- Lead Sponsor
- GlaxoSmithKline
- Target Recruit Count
- 4068
- Registration Number
- NCT01444612
Drug Development Updates
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