Tetracycline

Generic Name: Tetracycline

Brand Names: Pylera, Sumycin

Drug Type: Small Molecule

Chemical Formula: C_₂₂H_₂₄N_₂O_₈

CAS Number: 60-54-8

Unique Ingredient Identifier: F8VB5M810T

Background: Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some extent to the bacterial 50S ribosomal sub...

Indication: Used to treat bacterial infections such as Rocky Mountain spotted fever, typhus fever, tick fevers, Q fever, rickettsialpox and Brill-Zinsser disease. May be used to treat infections caused by Chlamydiae spp., B. burgdorferi (Lyme disease), and upper respiratory infections caused by typical (S. pneumoniae, H. influenzae, and M. catarrhalis) and atypical orga...

Associated Conditions: Acinetobacter Infections, Actinomycosis, Anthrax, Bacterial Infections, Bartonellosis, Brucellosis, Campylobacter Infection, Chancroid, Chlamydial Infections, Cholera (Disorder), Clostridium Infections, Conjunctivitis, Inclusion, Cystitis, Endometritis, Entamoebic histolytica infection, Escherichia infections, Granuloma Inguinale, Helicobacter Pylori Infection, Infection, Infection, Bacteroides, Klebsiella Infections, Listeria infection, Lower respiratory tract infection bacterial, Lymphogranuloma Venereum, Necrotizing ulcerative gingivostomatitis, Neisseria Gonorrhoeae Infection, Nephritis, Ornithosis, Plague, Prostatitis, Psittacosis, Q Fever, Relapsing Fever, Rickettsialpox, Rocky Mountain Spotted Fever, Rosacea, Severe Acne, Shigella Infection, Skin Infections caused by Staphylococcus Aureus, Skin and Subcutaneous Tissue Bacterial Infections, Syphilis, Trachoma, Tularemia, Typhus, Upper respiratory tract infection bacterial, Urinary Tract Infection, Yaws, Grade 1, grade 2, grade 3, grade 4 Urinary Tract Infection

Associated Therapies: -

Clinical Trials

Weekly Isotretinoin Vs Tetracycline for Moderate Acne

Early Phase 1

Not yet recruiting

Conditions: Acne Vulgaris

Interventions: Drug: Isotretinoin
Drug: Tetracycline

First Posted Date: 2024-01-26

Last Posted Date: 2024-10-30

Lead Sponsor: Medical University of South Carolina

Target Recruit Count: 50

Registration Number: NCT06225570

Helicobacter Rescue Therapy With Vonorazon and Amoxicillin Dual Therapy Versus Bismuth-containing Quadruple Therapy

Phase 4

Recruiting

Conditions: Gastritis Dyspepsia Helicobacter Pylori Infection Gastric Cancer Peptic Ulcer

Interventions: Drug: Bismuth
Drug: Vonoprazan
Drug: amoxicillin
Drug: Esomeprazole
Drug: Tetracycline
Drug: Furazolidone

First Posted Date: 2023-12-13

Last Posted Date: 2024-07-30

Lead Sponsor: Yongquan Shi

Target Recruit Count: 688

Registration Number: NCT06168084

Locations: 🇨🇳
Xijing Hosipital of Digestive Disease, Xi'an, Shanxi, China

Doxycycline for Helicobacter Pylori Rescue Treatment

Phase 4

Recruiting

Conditions: Helicobacter Pylori Infection

Interventions: Drug: Esomeprazole
Drug: Bismuth Potassium Citrate
Drug: Tetracycline
Drug: Doxycycline
Drug: Metronidazole

First Posted Date: 2023-05-25

Last Posted Date: 2023-09-25

Lead Sponsor: Shanghai Jiao Tong University School of Medicine

Target Recruit Count: 368

Registration Number: NCT05874570

Locations: 🇨🇳
Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, Shanghai, China

Rescue Therapy for Helicobacter Pylori Infection

Phase 4

Recruiting

Conditions: Helicobacter Pylori Infection

Interventions: Drug: Vonoprazan
Drug: Bismuth Potassium Citrate
Drug: Amoxicillin
Drug: Tetracycline
Drug: Rifabutin
Drug: Metronidazole

First Posted Date: 2023-05-25

Last Posted Date: 2024-10-22

Lead Sponsor: Shanghai Jiao Tong University School of Medicine

Target Recruit Count: 357

Registration Number: NCT05874544

Locations: 🇨🇳
Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, Shanghai, China
🇨🇳
Shanghai Songjiang District Central Hospital, Shanghai, Shanghai, China
🇨🇳
The Second Affiliated Hospital of Zhejiang University school of Medicine, Hangzhou, Zhejiang, China

Bismuth Quadruple Therapy for Helicobacter Pylori Rescue Therapy of Different Tetracycline Doses and Frequencies.

Phase 4

Recruiting

Conditions: Helicobacter Pylori Infection

Interventions: Drug: Tetracyclin

First Posted Date: 2022-06-27

Last Posted Date: 2023-01-31

Lead Sponsor: Shandong University

Target Recruit Count: 407

Registration Number: NCT05432115

Locations: 🇨🇳
Qilu Hospital, Jinan, Shandong, China

Susceptibility-Guided Therapy for Helicobacter Pylori Infection Treatment

Phase 4

Conditions: Helicobacter Pylori Infection

Interventions: Drug: Esomeprazole
Drug: Bismuth potassium citrate
Drug: Metronidazole
Drug: Clarithromycin
Drug: Levofloxacin
Drug: Amoxicillin
Drug: Tetracycline

First Posted Date: 2022-02-22

Last Posted Date: 2022-03-18

Lead Sponsor: Shanghai Zhongshan Hospital

Target Recruit Count: 388

Registration Number: NCT05250050

Locations: 🇨🇳
Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, Shanghai, China
🇨🇳
Huashan Hospital, Fudan University, Shanghai, Shanghai, China
🇨🇳
Zhongshan Hospital, Fudan University, Shanghai, Shanghai, China

Helicobacter Pylori Eradication and Follow-up

Phase 4

Recruiting

Conditions: Helicobacter Pylori Infection

Interventions: Drug: Rabeprazole
Drug: Bismuth potassium citrate
Drug: Metronidazole
Drug: Amoxicillin
Drug: Clarithromycin
Drug: Levofloxacin
Drug: Doxycycline
Drug: Tetracycline

First Posted Date: 2021-09-30

Last Posted Date: 2021-09-30

Lead Sponsor: Shanghai Zhongshan Hospital

Target Recruit Count: 4447

Registration Number: NCT05061732

Locations: 🇨🇳
Zhongshan Hospital, Fudan University, Shanghai, Shanghai, China

Bismuth-containing Quadruple Therapy for Helicobacter Pylori Eradication

Phase 4

Completed

Conditions: Helicobacter Pylori Infection

Interventions: Drug: Amoxicillin
Drug: Clarithromycin
Drug: Tetracycline
Drug: Metronidazole
Drug: Bismuth Potassium Citrate
Drug: Colloidal Bismuth Pectin
Drug: Vonoprazan fumarate

First Posted Date: 2021-09-20

Last Posted Date: 2023-07-19

Lead Sponsor: Shandong University

Target Recruit Count: 1300

Registration Number: NCT05049902

Locations: 🇨🇳
Maternity and Child Care Health Center of Dezhou, Dezhou, Shandong, China
🇨🇳
Heze Municipal 3rd people's hospital, Heze, Shandong, China
🇨🇳
Qilu hosipital, Jinan, Shandong, China

and more 3 locations