Diphenoxylate
- Generic Name
- Diphenoxylate
- Brand Names
- Lomotil
- Drug Type
- Small Molecule
- Chemical Formula
- C30H32N2O2
- CAS Number
- 915-30-0
- Unique Ingredient Identifier
- 73312P173G
- Background
A meperidine congener used as an antidiarrheal, usually in combination with atropine. At high doses, it acts like morphine. Its unesterified metabolite difenoxin has similar properties and is used similarly. It has little or no analgesic activity. This medication is classified as a Schedule V under the Controlled Substances Act by the Food and Drug Administration (FDA) and the DEA in the United States when used in preparations. When diphenoxylate is used alone, it is classified as a Schedule II.
- Indication
For as adjunctive therapy in the management of diarrhea
- Associated Conditions
- Diarrhea
Incidence and Severity of Diarrhea in Patients With HER2 Positive Breast Cancer Treated With Trastuzumab and Neratinib
- Conditions
- HER2-positive Breast CancerStage II Breast Cancer AJCC v6 and v7Breast AdenocarcinomaStage IIA Breast Cancer AJCC v6 and v7Stage IIIC Breast Cancer AJCC v7Stage IIIB Breast Cancer AJCC v7Stage IIB Breast Cancer AJCC v6 and v7Stage III Breast Cancer AJCC v7Stage IIIA Breast Cancer AJCC v7
- Interventions
- Biological: Trastuzumab
- First Posted Date
- 2017-03-29
- Last Posted Date
- 2023-11-18
- Lead Sponsor
- University of California, San Francisco
- Target Recruit Count
- 11
- Registration Number
- NCT03094052
- Locations
- 🇺🇸
University of California, San Francisco, San Francisco, California, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.