Diphenoxylate (Lomotil)

概览

Diphenoxylate is an antidiarrheal medication used with atropine to manage diarrhea.

作用机制

Diphenoxylate is an opiate receptor agonists that stimulate mu receptors in GI to decrease the peristalsis and constrict the sphincters. Diphenoxylate has a direct effect on circular smooth muscle of the bowel, that conceivably results in segmentation and prolongation of gastrointestinal transit time. The clinical antidiarrheal action of diphenoxylate may thus be a consequence of enhanced segmentation that allows increased contact of the intraluminal contents with the intestinal mucosa.

适应症

For as adjunctive therapy in the management of diarrhea

• Diarrhea