MedPath

Bleomycin

Generic Name
Bleomycin
Drug Type
Small Molecule
Chemical Formula
C55H84N17O21S3
CAS Number
11056-06-7
Unique Ingredient Identifier
40S1VHN69B

Overview

A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2 (B2 CAS # 9060-10-0). It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. Bleomycin A2 is used as the representative structure for Bleomycin.

Background

A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2 (B2 CAS # 9060-10-0). It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. Bleomycin A2 is used as the representative structure for Bleomycin.

Indication

For palliative treatment in the management malignant neoplasm (trachea, bronchus, lung), squamous cell carcinoma, and lymphomas.

Associated Conditions

  • Hodgkin's Lymphoma
  • Malignant Pleural Effusion
  • Non-Hodgkin's Lymphomas
  • Squamous Cell Carcinoma (SCC)
  • Teratocarcinoma
  • Testicular Choriocarcinoma
  • Testicular Embryonal Carcinoma

FDA Approved Products

Bleomycin
Manufacturer:NorthStar Rx LLC
Route:INTRAMUSCULAR, INTRAVENOUS, SUBCUTANEOUS, INTRAPLEURAL
Strength:30 [USP'U] in 1 1
Approved: 2018/11/20
NDC:16714-908
Bleomycin
Manufacturer:Hospira, Inc.
Route:INTRAMUSCULAR, INTRAVENOUS, SUBCUTANEOUS, INTRAPLEURAL
Strength:30 [USP'U] in 1 1
Approved: 2022/08/25
NDC:0409-0323
Bleomycin
Manufacturer:Hospira, Inc.
Route:INTRAMUSCULAR, INTRAVENOUS, SUBCUTANEOUS, INTRAPLEURAL
Strength:15 [USP'U] in 1 1
Approved: 2022/08/25
NDC:61703-332
Bleomycin
Manufacturer:Meitheal Pharmaceuticals Inc.
Route:INTRAMUSCULAR, INTRAVENOUS, SUBCUTANEOUS, INTRAPLEURAL
Strength:15 [USP'U] in 1 1
Approved: 2021/06/24
NDC:71288-106
Bleomycin
Manufacturer:NorthStar Rx LLC
Route:INTRAMUSCULAR, INTRAVENOUS, SUBCUTANEOUS, INTRAPLEURAL
Strength:15 [USP'U] in 1 1
Approved: 2018/11/20
NDC:16714-886

Singapore Approved Products

DBL BLEOMYCIN SULFATE FOR INJECTION 15000 iu/vial
Manufacturer:Zydus Hospira Oncology Private Limited (ZHOPL)
Form:INJECTION, POWDER, FOR SOLUTION
Strength:15000 iu/vial
Online:Yes
Approved: 1995/10/26
Approval:SIN08426P

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