The US is experiencing a significant H5N1 avian influenza outbreak affecting over 800 dairy herds across 16 states, with 66 confirmed human cases and one death reported in early 2025.
Arcturus Therapeutics has commenced a Phase 1 clinical trial for ARCT-2304 (LUNAR-H5N1), a self-amplifying mRNA vaccine targeting the H5N1 influenza virus.