Perifosine
未知生产厂商
Perifosine is a novel alkylphospholipid with antiproliferative properties attributed to protein kinase B inhibition.
Perifosine is a novel alkylphospholipid with antiproliferative properties attributed to protein kinase B inhibition.
Targeting cellular membranes, perifosine modulates membrane permeability, membrane lipid composition, phospholipid metabolism, and mitogenic signal transduction, resulting in cell differentiation and inhibition of cell growth. This agent also inhibits the anti-apoptotic mitogen-activated protein kinase (MAPK) pathway and modulates the balance between the MAPK and pro-apoptotic stress-activated protein kinase (SAPK/JNK) pathways, thereby inducing apoptosis.
Investigated for use/treatment in solid tumors, multiple myeloma, leukemia (unspecified), lung cancer, and brain cancer.
每项发明一条，涵盖美国、欧洲、PCT 与中国的同族专利。
