MedPath

Chlorpromazine

Generic Name
Chlorpromazine
Drug Type
Small Molecule
Chemical Formula
C17H19ClN2S
CAS Number
50-53-3
Unique Ingredient Identifier
U42B7VYA4P

Overview

The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.

Background

The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.

Indication

For the treatment of schizophrenia; to control nausea and vomiting; for relief of restlessness and apprehension before surgery; for acute intermittent porphyria; as an adjunct in the treatment of tetanus; to control the manifestations of the manic type of manic-depressive illness; for relief of intractable hiccups; for the treatment of severe behavioral problems in children (1 to 12 years of age) marked by combativeness and/or explosive hyperexcitable behavior (out of proportion to immediate provocations), and in the short-term treatment of hyperactive children who show excessive motor activity with accompanying conduct disorders consisting of some or all of the following symptoms: impulsivity, difficulty sustaining attention, aggressivity, mood lability, and poor frustration tolerance.

Associated Conditions

  • Acute Intermittent Porphyria (AIP)
  • Apprehension
  • Defiant Disorder, Oppositional
  • Intractable hiccups
  • Mania
  • Nausea and vomiting
  • Restlessness
  • Schizophrenia
  • Tetanus
  • Severe behavioural problems
  • Short term Hyperactivity

FDA Approved Products

Chlorpromazine Hydrochloride
Manufacturer:Sandoz, Inc.
Route:ORAL
Strength:30 mg in 1 mL
Approved: 2023/04/03
NDC:0781-4027
Chlorpromazine Hydrochloride
Manufacturer:Golden State Medical Supply, Inc.
Route:ORAL
Strength:100 mg in 1 1
Approved: 2022/12/14
NDC:51407-437
Chlorpromazine Hydrochloride
Manufacturer:Zydus Lifesciences Limited
Route:INTRAMUSCULAR
Strength:25 mg in 1 mL
Approved: 2024/03/14
NDC:70771-1778
Chlorpromazine Hydrochloride
Manufacturer:TYA Pharmaceuticals
Route:ORAL
Strength:100 mg in 1 1
Approved: 2011/11/23
NDC:64725-5916
Chlorpromazine hydrochloride
Manufacturer:Zydus Pharmaceuticals (USA) Inc.
Route:ORAL
Strength:200 mg in 1 1
Approved: 2023/09/18
NDC:70710-1133

Singapore Approved Products

CHLORPROMAZINE 100 TABLET 100 mg
Manufacturer:REMEDICA LTD
Form:TABLET, FILM COATED
Strength:100 mg
Online:Yes
Approved: 1993/10/26
Approval:SIN07528P
CHLORPROMAZINE 25 TABLET 25 mg
Manufacturer:REMEDICA LTD
Form:TABLET, FILM COATED
Strength:25 mg
Online:Yes
Approved: 1992/10/12
Approval:SIN07195P
LARGO TABLETS 25 mg
Manufacturer:BEACONS PHARMACEUTICALS PTE. LTD.
Form:TABLET, FILM COATED
Strength:25 mg
Online:Yes
Approved: 1988/03/16
Approval:SIN00095P
CHLORPROMAZINE HYDROCHLORIDE TABLET 50 mg
Manufacturer:REMEDICA LTD
Form:TABLET, FILM COATED
Strength:50 mg
Online:Yes
Approved: 1992/02/15
Approval:SIN06832P
LARGO TABLET 100 mg
Manufacturer:BEACONS PHARMACEUTICALS PTE. LTD.
Form:TABLET, FILM COATED
Strength:100 mg
Online:Yes
Approved: 1988/03/16
Approval:SIN00096P

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