Chlorpromazine
- Generic Name
- Chlorpromazine
- Brand Names
- -
- Drug Type
- Small Molecule
- Chemical Formula
- C17H19ClN2S
- CAS Number
- 50-53-3
- Unique Ingredient Identifier
- U42B7VYA4P
- Background
The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
- Indication
For the treatment of schizophrenia; to control nausea and vomiting; for relief of restlessness and apprehension before surgery; for acute intermittent porphyria; as an adjunct in the treatment of tetanus; to control the manifestations of the manic type of manic-depressive illness; for relief of intractable hiccups; for the treatment of severe behavioral prob...
- Associated Conditions
- Acute Intermittent Porphyria (AIP), Apprehension, Defiant Disorder, Oppositional, Intractable hiccups, Mania, Nausea and vomiting, Restlessness, Schizophrenia, Tetanus, Severe behavioural problems, Short term Hyperactivity
- Associated Therapies
- -
Managing Agitated Delirium with Neuroleptics and Anti-Epileptics As a Neuroleptic Sparing Strategy
- Conditions
- Interventions
- First Posted Date
- 2022-06-24
- Last Posted Date
- 2024-12-04
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 30
- Registration Number
- NCT05431595
- Locations
- 🇺🇸
MD Anderson Cancer Center, Houston, Texas, United States
Chlorpromazine and Standard of Care in Glioblastoma
- Conditions
- Interventions
- First Posted Date
- 2022-01-13
- Last Posted Date
- 2023-08-29
- Lead Sponsor
- Mohammed Milhem
- Target Recruit Count
- 10
- Registration Number
- NCT05190315
- Locations
- 🇺🇸
University of Iowa Hospitals & Clinics, Iowa City, Iowa, United States
Administration of Chlorpromazine as a Treatment for COVID-19
- First Posted Date
- 2020-04-21
- Last Posted Date
- 2020-07-08
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 100
- Registration Number
- NCT04354805
- Locations
- 🇪🇬
Cairo University, Cairo, Egypt
The Effect of Chlorpromazine on Esophageal Sensitivity in Healthy Volunteers.
- Conditions
- Interventions
- First Posted Date
- 2017-06-12
- Last Posted Date
- 2017-06-12
- Lead Sponsor
- Universitaire Ziekenhuizen KU Leuven
- Target Recruit Count
- 14
- Registration Number
- NCT03183310
- Locations
- 🇧🇪
Targid, KU Leuven, Leuven, Vlaams-Brabant, Belgium
Haloperidol With or Without Chlorpromazine in Treating Delirium in Patients With Advanced, Metastatic, or Recurrent Cancer
- First Posted Date
- 2017-01-16
- Last Posted Date
- 2024-10-03
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 70
- Registration Number
- NCT03021486
- Locations
- 🇺🇸
M D Anderson Cancer Center, Houston, Texas, United States
Assessment of Intra-subject Variability in the Bioavailability of Chlorpromazine Hydrochloride
- Conditions
- Anti-PsychoticControl Manifestations of the Manic Type of Mani-depressive IllnessControl Nausea and VomitingAdjunct in the Treatment of TetanusRelief of Intractable HiccupsManagement of Manifestations of Psychotic DisordersAcute Intermittent PorphyriaTreatment of SchizophreniaRelief of Restlessness and Apprehension Before Surgery
- Interventions
- First Posted Date
- 2016-10-24
- Last Posted Date
- 2017-11-14
- Lead Sponsor
- Cycle Pharmaceuticals Ltd.
- Target Recruit Count
- 20
- Registration Number
- NCT02943213
- Locations
- 🇿🇦
Farmovs Parexel, Bloemfontein, Kampuslaan Suid, South Africa
How to Treat Opiate Withdrawal in Neonates
- Conditions
- Interventions
- First Posted Date
- 2016-06-23
- Last Posted Date
- 2020-01-07
- Lead Sponsor
- University of Zurich
- Target Recruit Count
- 120
- Registration Number
- NCT02810782
Family Intervention in Recent Onset Schizophrenia Treatment (FIRST)
- Conditions
- Interventions
- Other: Caregiver psycho-education and skills trainingOther: Caregiver support available at the study siteDrug: Paliperidone palmitateDrug: ChlorpromazineDrug: DroperidolDrug: FluphenazineDrug: HaloperidolDrug: LoxapineDrug: PerphenazineDrug: PimozideDrug: ProchlorperazineDrug: ThiothixeneDrug: ThioridazineDrug: TrifluoperazineDrug: AripiprazoleDrug: AsenapineDrug: ClozapineDrug: IloperidoneDrug: OlanzapineDrug: PaliperidoneDrug: QuetiapineDrug: RisperidoneDrug: Ziprasidone
- First Posted Date
- 2015-11-09
- Last Posted Date
- 2019-01-23
- Lead Sponsor
- Janssen Scientific Affairs, LLC
- Target Recruit Count
- 296
- Registration Number
- NCT02600741
Use of Intravitreal Triamcinolone and Retrobulbar Chlorpromazine as Alternatives to the Management of Painful Blind Eye
- Conditions
- Interventions
- First Posted Date
- 2011-07-28
- Last Posted Date
- 2011-07-28
- Lead Sponsor
- Hospital Governador Celso Ramos
- Target Recruit Count
- 36
- Registration Number
- NCT01404364
- Locations
- 🇧🇷
Hospital Governador Celso Ramos, Florianopolis, Santa Catarina, Brazil
Efficacy and Safety of Quetiapine Fumarate in the Treatment of Schizophrenic Patients
- Conditions
- Interventions
- First Posted Date
- 2009-04-16
- Last Posted Date
- 2012-05-15
- Lead Sponsor
- AstraZeneca
- Target Recruit Count
- 388
- Registration Number
- NCT00882518
- Locations
- 🇨🇳
Research Site, Shanghai, China
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.