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Travoprost

Generic Name
Travoprost
Brand Names
Duotrav, Izba, Travatan
Drug Type
Small Molecule
Chemical Formula
C26H35F3O6
CAS Number
157283-68-6
Unique Ingredient Identifier
WJ68R08KX9
Background

Travoprost ophthalmic solution is a topical medication used for controlling the progression of glaucoma or ocular hypertension, by reducing intraocular pressure . It is a synthetic prostaglandin F2alpha analog . Having been a well-received therapeutic agent with demonstrated efficacy and safety, travoprost is currently approved by the US FDA as a first-line treatment for lowering intraocular pressure in patients with open-angle glaucoma or ocular hypotension . Furthermore, this approval also solidifies the medication as the first and only prostaglandin analog approved by the FDA for first-line treatment of glaucoma patients that does not contain the preservative benzalkonium chloride . Moreover, travoprost is also currently approved in the EU for the decrease of elevated intraocular pressure in paediatric patients aged 2 months to < 18 years with ocular hypertension or paediatric glaucoma .

Indication

Travoprost ophthalmic solution is indicated for the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension .

Travoprost is also currently indicated for the decrease of elevated intraocular pressure in paediatric patients aged 2 months to < 18 years with ocular hypertension or paediatric glaucoma .

Associated Conditions
Increased Intra Ocular Pressure (IOP)
Associated Therapies
-

Effects of Travoprost on Neovascular Glaucoma

Not Applicable
Withdrawn
Conditions
Neovascular Glaucoma
First Posted Date
2007-02-28
Last Posted Date
2011-06-22
Lead Sponsor
Federal University of São Paulo
Target Recruit Count
40
Registration Number
NCT00441181
Locations
🇧🇷

Federal University of São Paulo, São Paulo, Brazil

Mechanism of Action of TRAVATAN 0.004% in Subjects With Glaucoma or Ocular Hypertension

Phase 4
Completed
Conditions
Glaucoma
Ocular Hypertension
First Posted Date
2003-05-30
Last Posted Date
2008-08-05
Lead Sponsor
Alcon Research
Registration Number
NCT00061503
Locations
🇺🇸

Alcon Call Center, Call for Details, Nebraska, United States

A Safety and Efficacy Study of Travoprost 0.004% Compared to Latanoprost 0.005% in Patients With Open-Angle Glaucoma (OAG) or Ocular Hypertension (OHT)

Phase 3
Completed
Conditions
Glaucoma, Open-Angle
Ocular Hypertension
First Posted Date
2003-01-07
Last Posted Date
2008-08-05
Lead Sponsor
Alcon Research
Registration Number
NCT00051142
Locations
🇺🇸

Latin America, Fort Worth, Texas, United States

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