A Comprehensive Pharmacological and Clinical Review of Policresulen and Dibucaine Hydrochloride

1.0 Executive Summary & Therapeutic Overview

1.1 Introduction to the Combination Therapy

The combination of Policresulen and Dibucaine hydrochloride is a topical therapeutic agent formulated for the treatment of localized anorectal and gynecological conditions.[1] This product leverages a synergistic mechanism, uniting the distinct pharmacological actions of its two active pharmaceutical ingredients. Policresulen contributes antiseptic, hemostatic, and tissue-regenerating properties, while Dibucaine hydrochloride provides potent local anesthetic effects to alleviate pain and pruritus.[1] The primary clinical indications for this combination therapy include the management of hemorrhoids (piles), particularly those associated with inflammation and bleeding, and anal fissures.[3] It is available in formulations such as rectal ointments and suppositories to facilitate direct application to the affected mucosal tissues.[2]

1.2 Therapeutic Rationale and Clinical Positioning