Sodium bicarbonate

Generic Name: Sodium bicarbonate

Brand Names: Alka-seltzer, Alka-seltzer Fruit Chews, Alka-seltzer Heartburn Relief, Bi-peglyte, Bibag, Bicart, Bss Ophthalmic Solution, Ceo-two, Colyte, Gavilyte-C, Gavilyte-G, Gavilyte-H and Bisacodyl, Gavilyte-N, Golytely, H.E.L.P.bicel, Hema Bp-38, Hemacart, Konvomep, Nulytely, Peglyte, Phoxillum, Physioneal 40, Prismasol, Zegerid, Zegerid Reformulated Aug 2006, Zegerid With Magnesium Hydroxide

Drug Type: Small Molecule

Chemical Formula: CHNaO_₃

CAS Number: 144-55-8

Unique Ingredient Identifier: 8MDF5V39QO

Background: Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.

Indication: Sodium bicarbonate is used for the treatment of metabolic acidosis which may occur in severe renal disease, uncontrolled diabetes, circulatory insufficiency due to shock or severe dehydration, extracorporeal circulation of blood, cardiac arrest and severe primary lactic acidosis. Also is indicated in severe diarrhea which is often accompanied by a significan...

Associated Conditions: Barbiturate intoxication, Breast Cancer, Constipation, Dental Decay, Duodenal Ulcer, Dyspepsia, Gastro-esophageal Reflux Disease (GERD), Gingival Bleeding, Heartburn, Helicobacter Infections, Hyperkalemia, Ischaemia, Metabolic Acidosis, Myocardial Infarction, Plaque, Dental, Pruritis of the skin, Skin Irritation, Upper GI Bleeding, Upset stomach, Zollinger-Ellison Syndrome, Abdominal bloating, Benign, active Gastric Ulcer, Methyl alcohol poisoning, Prophylaxis of Contrast-induced nephropathy, Salicylate poisoning, Severe Diarrhea, Swelling of the gums

Associated Therapies: Bowel preparation therapy

Clinical Trials

The Role of Sodium Bicarbonate as Adjuvant Treatment of Computed Tomography Identified COVID-19 Pneumonia

Not Applicable

Conditions: Covid19
Pneumonia

Interventions: Drug: Sodium Bicarbonate

First Posted Date: 2020-05-05

Last Posted Date: 2020-10-06

Lead Sponsor: Mansoura University

Target Recruit Count: 180

Registration Number: NCT04374591

Locations: 🇪🇬
Gomhoria Street, Mansoura, Outside U.S./Canada, Egypt

Intra-arterial Infusion Chemotherapy Combined With Sodium Bicarbonate for Unresectable Gastric Cancer

Early Phase 1

Conditions: Successful Conversion Rate of Operation
Unresectable Gastric Cancer

Interventions: Drug: Systemic Chemotherapy
Drug: Arterial catheter infusion chemotherapy
Drug: Sodium Bicarbonate
Drug: Oral Chemotherapy

First Posted Date: 2019-01-30

Last Posted Date: 2019-02-20

Lead Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

Target Recruit Count: 150

Registration Number: NCT03822130

Locations: 🇨🇳
The Second affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China

Bicarbonate Administration in Kidney Transplant Recipients

Not Applicable

Completed

Conditions: Kidney Transplant; Complications
Metabolic Acidosis

Interventions: Other: Placebo
Drug: Sodium Bicarbonate

First Posted Date: 2018-02-09

Last Posted Date: 2020-10-22

Lead Sponsor: University of Colorado, Denver

Target Recruit Count: 20

Registration Number: NCT03428464

Locations: 🇺🇸
University of Colorado Hospital, Aurora, Colorado, United States

The Efficiency and Safety of Sodium Bicarbonate on Uric Acid in Patients With Asymptomatic Hyperuricemia or Gout

Not Applicable

Conditions: Asymptomatic Hyperuricemia
Gout

Interventions: Drug: Sodium Bicarbonate

First Posted Date: 2017-10-11

Last Posted Date: 2017-10-11

Lead Sponsor: Shanghai Zhongshan Hospital

Target Recruit Count: 104

Registration Number: NCT03306758

Preventing contrAst Induced Nephropathy After TranscathEter Aortic Valve Replacement

Phase 4

Conditions: Aortic Valve Disease
Chronic Kidney Disease
Contrast Induced Nephropathy
Acute Kidney Injury

Interventions: Drug: hypotone saline
Drug: sodium bicarbonate

First Posted Date: 2017-04-19

Last Posted Date: 2017-04-19

Lead Sponsor: St. Antonius Hospital

Target Recruit Count: 200

Registration Number: NCT03121053

Locations: 🇳🇱
St Antonius hospital, Nieuwegein, Utrecht, Netherlands

Impact of NaHCO3- on Exercise Hyperpnea

Early Phase 1

Completed

Conditions: Pulmonary Ventilation

Interventions: Drug: Sodium Bicarbonate
Drug: Sodium Chloride

First Posted Date: 2017-02-20

Last Posted Date: 2017-02-20

Lead Sponsor: McGill University

Target Recruit Count: 20

Registration Number: NCT03057535

Locations: 🇨🇦
McGill University, Department of Kinesiology & Physical Education, Clinical Exercise & Respiratory Physiology Laboratory, Montreal, Quebec, Canada