Mitomycins
- Generic Name
- Mitomycins
- Brand Names
- Jelmyto, Mitosol, Mutamycin
- Drug Type
- Small Molecule
- Chemical Formula
- C15H18N4O5
- CAS Number
- 50-07-7
- Unique Ingredient Identifier
- 50SG953SK6
- Background
Mitomycin is an antineoplastic antibiotic first isolated by Japanese microbiologists in the 1950s from cultures of Streptomyces caespitosus. It is an alkylating agent that inhibits DNA synthesis (and, at higher concentrations, RNA and protein synthesis) by cross-linking the complementary strands of the DNA double helix. Few other antibiotics have been discov...
- Indication
For treatment of malignant neoplasm of lip, oral cavity, pharynx, digestive organs, peritoneum, female breast, and urinary bladder. Also used as an adjunct to ab externo glaucoma surgery. Mitomycin is also indicated as a pyelocalyceal solution for the treatment of adults with low-grade upper tract urothelial cancer (LG-UTUC).
- Associated Conditions
- Anal Cancer, Bladder Cancer, Breast Cancer, Carcinoma of the Head and Neck, Cervical Cancer, Gastric Adenocarcinoma, Mesothelioma, Non-Small Cell Lung Cancer (NSCLC), Pancreatic Adenocarcinoma, Ab externo surgery Glaucoma, Low-grade Upper Tract Urothelial Cancer (LG-UTUC)
- Associated Therapies
- -
Radiation Therapy, Mitomycin, and Either Fluorouracil or Cisplatin in Treating Patients With Locally Advanced Anal Cancer
- Conditions
- First Posted Date
- 2003-09-11
- Last Posted Date
- 2012-09-24
- Target Recruit Count
- 88
- Registration Number
- NCT00068744
- Locations
- 🇷🇸
Institute of Oncology and Radiology of Serbia, Belgrade, Serbia
🇧🇪Ziekenhuis Netwerk Antwerpen Middelheim, Antwerpen, Belgium
🇧🇪Cazk Groeninghe - Campus Maria's Voorzienigheid, Kortrijk, Belgium
Paclitaxel and Carboplatin Chemotherapy Compared With Standard Chemotherapy in Treating Patients With Stage III or Stage IV Non-small Cell Lung Cancer That Cannot Be Removed During Surgery
- Conditions
- First Posted Date
- 2003-07-24
- Last Posted Date
- 2013-09-20
- Lead Sponsor
- The Christie NHS Foundation Trust
- Registration Number
- NCT00004887
- Locations
- 🇬🇧
Christie Hospital N.H.S. Trust, Manchester, England, United Kingdom
Combination Chemotherapy With or Without Chemoembolization in Treating Patients With Colorectal Cancer Metastatic to the Liver (6655)
- Conditions
- First Posted Date
- 2003-06-17
- Last Posted Date
- 2020-12-02
- Lead Sponsor
- American College of Radiology Imaging Network
- Registration Number
- NCT00023868
- Locations
- 🇺🇸
Arizona Cancer Center, Tucson, Arizona, United States
🇺🇸H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States
🇺🇸Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States
Adjuvant Chemotherapy Plus Radiation Therapy in Treating Women With Early-Stage Breast Cancer
- Conditions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2013-12-19
- Lead Sponsor
- University Hospital Birmingham
- Target Recruit Count
- 2250
- Registration Number
- NCT00003893
- Locations
- 🇬🇧
Queen Elizabeth Hospital at University of Birmingham, Birmingham, England, United Kingdom
Combination Chemotherapy in Treating Patients With Stage IIIB or Stage IV Non-small Cell Lung Cancer
- Conditions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2013-12-18
- Lead Sponsor
- Raghu Nandan, M.D., Inc
- Registration Number
- NCT00005825
- Locations
- 🇺🇸
Rajendra Prasad M.D., Inc., Lakewood, California, United States
Radiation Therapy With or Without Chemotherapy in Treating Patients With Stage II or Stage III Bladder Cancer
- Conditions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2013-12-18
- Lead Sponsor
- University Hospital Birmingham
- Target Recruit Count
- 350
- Registration Number
- NCT00024349
- Locations
- 🇬🇧
Queen Elizabeth Hospital at University Hospital of Birmingham NHS Trust, Birmingham, England, United Kingdom
🇬🇧St. Thomas' Hospital, London, England, United Kingdom
🇬🇧Royal Marsden NHS Foundation Trust - Surrey, Sutton, England, United Kingdom
Radiation Therapy, Chemotherapy, or Observation in Treating Patients With Bladder Cancer
- Conditions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2013-12-18
- Lead Sponsor
- Medical Research Council
- Registration Number
- NCT00002490
- Locations
- 🇬🇧
Middlesex Hospital- Meyerstein Institute, London, England, United Kingdom
Surgery With or Without Preoperative Chemotherapy in Treating Patients With Resectable Non-small Cell Lung Cancer
- Conditions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2013-12-04
- Lead Sponsor
- Medical Research Council
- Target Recruit Count
- 600
- Registration Number
- NCT00003159
- Locations
- 🇬🇧
Medical Research Council Clinical Trials Unit, London, England, United Kingdom
🇬🇧Royal Marsden NHS Foundation Trust - Surrey, Sutton, England, United Kingdom
Combination Chemotherapy Plus Sargramostim in Treating Patients With Cancer of the Uterus
- Conditions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2013-04-11
- Lead Sponsor
- Gynecologic Oncology Group
- Registration Number
- NCT00033644
- Locations
- 🇺🇸
Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, California, United States
🇺🇸Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois, United States
🇺🇸Tuft-New England Medical Center, Boston, Massachusetts, United States
BCG With or Without Mitomycin in Treating Patients With Bladder Cancer
- Conditions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2012-09-24
- Target Recruit Count
- 97
- Registration Number
- NCT00023842
- Locations
- 🇧🇪
Virga Jesse Hospital, Hasselt, Belgium
🇧🇪Universitair Ziekenhuis Gent, Ghent, Belgium
🇮🇹Ospedale di Circolo e Fondazione Macchi, Varese, Italy
Drug Development Updates
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