Mitomycins

Generic Name
Mitomycins
Brand Names
Jelmyto, Mitosol, Mutamycin
Drug Type
Small Molecule
Chemical Formula
C15H18N4O5
CAS Number
50-07-7
Unique Ingredient Identifier
50SG953SK6
Background

Mitomycin is an antineoplastic antibiotic first isolated by Japanese microbiologists in the 1950s from cultures of Streptomyces caespitosus. It is an alkylating agent that inhibits DNA synthesis (and, at higher concentrations, RNA and protein synthesis) by cross-linking the complementary strands of the DNA double helix. Few other antibiotics have been discov...

Indication

For treatment of malignant neoplasm of lip, oral cavity, pharynx, digestive organs, peritoneum, female breast, and urinary bladder. Also used as an adjunct to ab externo glaucoma surgery. Mitomycin is also indicated as a pyelocalyceal solution for the treatment of adults with low-grade upper tract urothelial cancer (LG-UTUC).

Associated Conditions
Anal Cancer, Bladder Cancer, Breast Cancer, Carcinoma of the Head and Neck, Cervical Cancer, Gastric Adenocarcinoma, Mesothelioma, Non-Small Cell Lung Cancer (NSCLC), Pancreatic Adenocarcinoma, Ab externo surgery Glaucoma, Low-grade Upper Tract Urothelial Cancer (LG-UTUC)
Associated Therapies
-
Clinical Trials
Related News

Adaptive Radiation in Anal Cancer

First Posted Date
2023-05-01
Last Posted Date
2024-07-11
Lead Sponsor
Columbia University
Target Recruit Count
20
Registration Number
NCT05838391
Locations
🇺🇸

Columbia University Irving Medical Center, New York, New York, United States

Clinical Study of Curcumin in Preventing Postoperative Adhesion of Bilateral Vocal Cords

First Posted Date
2023-01-18
Last Posted Date
2023-05-06
Lead Sponsor
Eye & ENT Hospital of Fudan University
Target Recruit Count
100
Registration Number
NCT05688488
Locations
🇨🇳

Eye & ENT Hospital of Fudan University, Shanghai, Shanghai, China

Transarterial Chemoembolization for the Treatment of Lung Cancer and Lung Metastases

First Posted Date
2023-01-05
Last Posted Date
2024-11-28
Lead Sponsor
City of Hope Medical Center
Target Recruit Count
30
Registration Number
NCT05672108
Locations
🇺🇸

City of Hope Medical Center, Duarte, California, United States

🇺🇸

Memorial Sloan Kettering Cancer Center, New York, New York, United States

Comparison Between Topical Mitomycin C and Cyclosporine

Phase 1
Completed
Conditions
Pterygium
Interventions
Drug: Mitomycin c
First Posted Date
2022-11-28
Last Posted Date
2023-10-17
Lead Sponsor
Egymedicalpedia
Target Recruit Count
57
Registration Number
NCT05627947
Locations
🇪🇬

Faculty of Medicine, Menoufia University, Shibīn Al Kawm, Egypt

Guiding Instillation in Non Muscle-invasive Bladder Cancer Based on Drug Screens in Patient Derived Organoids

First Posted Date
2021-08-27
Last Posted Date
2022-11-22
Lead Sponsor
Insel Gruppe AG, University Hospital Bern
Target Recruit Count
33
Registration Number
NCT05024734
Locations
🇨🇭

Roland Seiler, Biel, Switzerland

Therapy Adapted for High Risk and Low Risk HIV-Associated Anal Cancer

Phase 2
Recruiting
Conditions
AIDS-Related Anal Carcinoma
Anal Margin Squamous Cell Carcinoma
Anal Non-Keratinizing Squamous Cell Carcinoma
Anal Squamous Cell Carcinoma
HIV Infection
Rectal Squamous Cell Carcinoma
Stage II Rectal Cancer AJCC v8
Stage IIB Anal Cancer AJCC v8
Stage III Anal Cancer AJCC v8
Stage III Rectal Cancer AJCC v8
Interventions
Procedure: Anoscopy
Procedure: Biospecimen Collection
Procedure: Colonoscopy
Drug: Capecitabine
Procedure: Computed Tomography
Procedure: Digital Rectal Examination
Procedure: Echocardiography
Biological: Nivolumab
Procedure: Proctoscopy
Other: Fludeoxyglucose F-18
Other: Questionnaire Administration
Drug: Fluorouracil
Procedure: Sigmoidoscopy
Radiation: Intensity-Modulated Radiation Therapy
Procedure: Lymph Node Biopsy
Procedure: Magnetic Resonance Imaging
Drug: Mitomycin
Procedure: Positron Emission Tomography
First Posted Date
2021-06-18
Last Posted Date
2024-11-13
Lead Sponsor
National Cancer Institute (NCI)
Target Recruit Count
40
Registration Number
NCT04929028
Locations
🇺🇸

Zuckerberg San Francisco General Hospital, San Francisco, California, United States

🇺🇸

George Washington University Medical Center, Washington, District of Columbia, United States

🇺🇸

Moffitt Cancer Center, Tampa, Florida, United States

and more 10 locations

Individualized Response Assessment to Heated Intraperitoneal Chemotherapy (HIPEC) for the Treatment of Peritoneal Carcinomatosis From Ovarian, Colorectal, Appendiceal, or Peritoneal Mesothelioma Histologies

First Posted Date
2021-04-15
Last Posted Date
2024-12-16
Lead Sponsor
National Cancer Institute (NCI)
Target Recruit Count
60
Registration Number
NCT04847063
Locations
🇺🇸

National Institutes of Health Clinical Center, Bethesda, Maryland, United States

Comparative Study of Mitomycin and Lobaplatin in Advanced Colorectal Cancer Patients With Radical Surgery Combined With Hyperthermic Intraperitoneal Chemotherapy

First Posted Date
2021-04-15
Last Posted Date
2022-02-21
Lead Sponsor
Wuhan Union Hospital, China
Target Recruit Count
201
Registration Number
NCT04845490

Conjunctival Vascularity Changes Usnig OCTA After Trabeculectomy

First Posted Date
2020-07-30
Last Posted Date
2020-07-30
Lead Sponsor
Asmaa Ahmed Ali Youssif
Target Recruit Count
100
Registration Number
NCT04493073

PIPAC for the Treatment of Peritoneal Carcinomatosis in Patients With Ovarian, Uterine, Appendiceal, Colorectal, or Gastric Cancer

First Posted Date
2020-04-01
Last Posted Date
2024-07-18
Lead Sponsor
City of Hope Medical Center
Target Recruit Count
49
Registration Number
NCT04329494
Locations
🇺🇸

Northwell Health Cancer Institute at Huntington, Greenlawn, New York, United States

🇺🇸

Mayo Clinic in Florida, Jacksonville, Florida, United States

🇺🇸

City of Hope Medical Center, Duarte, California, United States

© Copyright 2024. All Rights Reserved by MedPath
HomeTerms & ConditionsPrivacy Policy