Mitomycins
- Generic Name
- Mitomycins
- Brand Names
- Jelmyto, Mitosol, Mutamycin
- Drug Type
- Small Molecule
- Chemical Formula
- C15H18N4O5
- CAS Number
- 50-07-7
- Unique Ingredient Identifier
- 50SG953SK6
- Background
Mitomycin is an antineoplastic antibiotic first isolated by Japanese microbiologists in the 1950s from cultures of Streptomyces caespitosus. It is an alkylating agent that inhibits DNA synthesis (and, at higher concentrations, RNA and protein synthesis) by cross-linking the complementary strands of the DNA double helix. Few other antibiotics have been discov...
- Indication
For treatment of malignant neoplasm of lip, oral cavity, pharynx, digestive organs, peritoneum, female breast, and urinary bladder. Also used as an adjunct to ab externo glaucoma surgery. Mitomycin is also indicated as a pyelocalyceal solution for the treatment of adults with low-grade upper tract urothelial cancer (LG-UTUC).
- Associated Conditions
- Anal Cancer, Bladder Cancer, Breast Cancer, Carcinoma of the Head and Neck, Cervical Cancer, Gastric Adenocarcinoma, Mesothelioma, Non-Small Cell Lung Cancer (NSCLC), Pancreatic Adenocarcinoma, Ab externo surgery Glaucoma, Low-grade Upper Tract Urothelial Cancer (LG-UTUC)
- Associated Therapies
- -
A Prospective Study To Evaluate The Raindrop Near Vision Inlay In Presybopic or Pseudophakic Patients Treated With Mitomycin C Following Femtosecond Flap Creation.
- Conditions
- Interventions
- First Posted Date
- 2017-04-05
- Last Posted Date
- 2022-08-18
- Lead Sponsor
- Key-Whitman Eye Center
- Target Recruit Count
- 9
- Registration Number
- NCT03101501
- Locations
- 🇺🇸
Key-Whitman Eye Center, Dallas, Texas, United States
🇺🇸Chu Vision Institue, Bloomington, Minnesota, United States
🇺🇸Parkhurst NuVision, San Antonio, Texas, United States
Heated Intraperitoneal Chemotherapy and Gastrectomy for Gastric Cancer With Positive Peritoneal Cytology
- Conditions
- Interventions
- First Posted Date
- 2017-03-28
- Last Posted Date
- 2024-08-20
- Lead Sponsor
- National Cancer Institute (NCI)
- Target Recruit Count
- 27
- Registration Number
- NCT03092518
- Locations
- 🇺🇸
National Institutes of Health Clinical Center, Bethesda, Maryland, United States
Comparing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (CRS-HIPEC) Using Mitomycin-C Versus Melphalan for Colorectal Peritoneal Carcinomatosis
- Conditions
- Interventions
- First Posted Date
- 2017-03-08
- Last Posted Date
- 2023-06-09
- Lead Sponsor
- University of Kansas Medical Center
- Target Recruit Count
- 100
- Registration Number
- NCT03073694
- Locations
- 🇺🇸
The University of Kansas Medical Center, Westwood, Kansas, United States
Surgical Approaches in Treating Uncontrolled Glaucoma in Black African and African-Caribbeans
- Conditions
- Interventions
- First Posted Date
- 2016-12-12
- Last Posted Date
- 2016-12-12
- Lead Sponsor
- Guy's and St Thomas' NHS Foundation Trust
- Target Recruit Count
- 60
- Registration Number
- NCT02989207
- Locations
- 🇬🇧
St Thomas Hospital, London, United Kingdom
Study to Evaluate the Efficacy and Safety Of Intravesical Nanoxel®M In BCG Refractory NMIBC
- Conditions
- Interventions
- First Posted Date
- 2016-12-05
- Last Posted Date
- 2019-08-30
- Lead Sponsor
- Samyang Biopharmaceuticals Corporation
- Target Recruit Count
- 36
- Registration Number
- NCT02982395
- Locations
- 🇰🇷
Seoul National University Hospital, Seoul, Korea, Republic of
Bevacizumab Versus Mitomycin C as Trabeculectomy Adjuvant in Uncontrolled Glaucoma
- Conditions
- Interventions
- First Posted Date
- 2016-09-15
- Last Posted Date
- 2016-09-15
- Lead Sponsor
- Athens Vision Eye Institute
- Target Recruit Count
- 40
- Registration Number
- NCT02901236
Heated Mitomycin and Cisplatin During Surgery in Treating Patients With Stomach or Gastroesophageal Cancer
- First Posted Date
- 2016-09-07
- Last Posted Date
- 2023-04-13
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 24
- Registration Number
- NCT02891447
- Locations
- 🇺🇸
M D Anderson Cancer Center, Houston, Texas, United States
Ahmed Glaucoma Valve Surgery With Mitomycin-C
- First Posted Date
- 2016-06-17
- Last Posted Date
- 2022-05-31
- Lead Sponsor
- University of California, San Francisco
- Target Recruit Count
- 119
- Registration Number
- NCT02805257
- Locations
- 🇨🇳
Zhongshan Ophthalmic Center, Guangzhou, Guangdong, China
🇮🇳Shri Ganesh Vinayak Eye Hospital, Raipur, Chhattisgarh, India
🇺🇸University of California, San Francisco, San Francisco, California, United States
Risk Enabled Therapy After Initiating Neoadjuvant Chemotherapy for Bladder Cancer (RETAIN)
- First Posted Date
- 2016-03-17
- Last Posted Date
- 2023-12-11
- Lead Sponsor
- Fox Chase Cancer Center
- Target Recruit Count
- 78
- Registration Number
- NCT02710734
- Locations
- 🇺🇸
Johns Hopkins, Baltimore, Maryland, United States
🇺🇸Sidney kimmel Cancer Center, Philadelphia, Pennsylvania, United States
🇺🇸Washington Cancer Institute at MedStar Washington Hospital Center, Washington, District of Columbia, United States
The Bladder Instillation Comparison Study
- First Posted Date
- 2016-03-01
- Last Posted Date
- 2023-04-21
- Lead Sponsor
- Spectrum Health Hospitals
- Target Recruit Count
- 101
- Registration Number
- NCT02695771
- Locations
- 🇺🇸
Spectrum Health Medical Group-Division of Urology-LHCP, Grand Rapids, Michigan, United States
🇺🇸Spectrum Health Medical Group-Division of Urology, Grand Rapids, Michigan, United States
🇺🇸Urologic Consultants P.C., Grand Rapids, Michigan, United States
Drug Development Updates
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