烟酸甲酯

概览

Methyl nicotinate is a methyl ester of niacin used to treat muscle and joint pain.

作用机制

While the mechanism of action of methyl nicotinate and other topically-administered nicotinic acid esters is not clear, it is thought that methyl nicotinate promotes the release of prostaglandin D2 that is strictly locally-acting due to its short half-life . It was demonstrated in human subjects that the local cutaneous vascular response to methyl nicotinic was suppressed by inhibitors of prostaglandin biosynthesis, indicating that the effect of methyl nicotinate on vascular smooth muscles may be mediated by the release of local prostaglandins . Prostaglandins released from the skin and blood vessels induce cutaneous vasodilation .

适应症

Indicated for the temporary relief of aches and pains in muscles, tendons, and joints.

• Generalized joint pain
• Localized muscle pain
• Myalgia