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Apan (PPI-1019) is developed by Praecis Pharmaceuticals to treat Alzheimer's Disease.
Apan (PPI-1019) is developed by Praecis Pharmaceuticals to treat Alzheimer's Disease.
PPI-1019 (Apan) inhibits the aggregation of beta-amyloid and its associated nerve cell toxicity. In addition, Apan reaches the brain in quantities that are sufficient to block the aggregation of beta-amyloid molecules and alter the course of the disease. Accumulation of beta-amyloid in the brain is often thought of as a defect in the ability to clear beta-amyloid from the brain through the cerebral spinal fluid (CSF). Both humans and transgenic mice with Alzheimer's disease plaques show increased levels of beta-amyloid in the brain and decreased levels in the CSF. Transgenic mice treated with Apan show significant increases in beta-amyloid levels in the CSF, indicating that Apan is able to mobilize beta-amyloid in the brain and may be facilitating its clearance.
Investigated for use/treatment in alzheimer's disease.
每项发明一条，涵盖美国、欧洲、PCT 与中国的同族专利。
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