Heparin

Generic Name: Heparin

Brand Names: Heparin Leo

Drug Type: Small Molecule

Chemical Formula: -

CAS Number: 9005-49-6

Unique Ingredient Identifier: T2410KM04A

Background: Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (fac...

Indication: Unfractionated heparin is indicated for prophylaxis and treatment of venous thrombosis and its extension, prevention of post-operative deep venous thrombosis and pulmonary embolism and prevention of clotting in arterial and cardiac surgery. In cardiology, it is used to prevent embolisms in patients with atrial fibrillation and as an adjunct antithrombin ther...

Associated Conditions: Blunt Injury, Clotting, Coagulopathy, Consumption, Contusions, Deep vein thrombosis postoperative, Disseminated Intravascular Coagulation (DIC), External Hemorrhoid, Inflammation, Inflammatory, non-infectious pruritic dermatosis, Interstitial Cystitis, Post procedural pulmonary embolism, Pulmonary Embolism, ST Segment Elevation Myocardial Infarction (STEMI), Sprains, Thromboembolism, Unstable Angina Pectoris, Venous Thrombosis (Disorder), Hematomas, Peripheral arterial embolism, Thromboembolic phenomena, Varicosities of the great saphenous vein

Associated Therapies: Circulation, Extracorporeal, Dialysis therapy, Transfusions, Maintenance of patency of IV injection devices

Clinical Trials

The Effect of Exercise on Pharmacodynamics and Pharmacokinetics of a Single Dose of Unfractionated Heparin

Phase 4

Completed

Conditions: Blood Coagulation Disorder

Interventions: Drug: Unfractionated heparin
Behavioral: Double-legged cycle ergometer exercise
Behavioral: Single-legged cycle ergometer exercise, with unfractionated heparin injection in the exercising leg
Behavioral: No exercise
Behavioral: Single-legged cycle ergometer exercise, with unfractionated heparin injection in the non-exercising leg

First Posted Date: 2023-12-18

Last Posted Date: 2024-06-26

Lead Sponsor: Kristian Karstoft

Target Recruit Count: 23

Registration Number: NCT06174961

Locations: 🇩🇰
Bispebjerg-Frederiksberg Hospital, Department of Clinical Pharmacology, Copenhagen, Denmark

Comparison Between Haparin and Herodin in HD

Early Phase 1

Not yet recruiting

Conditions: Haemodialysis

Interventions: Drug: Heparin

First Posted Date: 2023-11-01

Last Posted Date: 2023-11-21

Lead Sponsor: Basma Rabiey

Target Recruit Count: 98

Registration Number: NCT06112262

Monitoring Anticoagulation in Patients on ECMO for Severe Lung Failure

Completed

Conditions: COVID-19
ARDS

Interventions: Drug: Argatroban Injection
Drug: Heparin

First Posted Date: 2023-09-15

Last Posted Date: 2024-03-01

Lead Sponsor: University Hospital Ostrava

Target Recruit Count: 100

Registration Number: NCT06038682

Locations: 🇨🇿
University Hospital Ostrava, Ostrava, Moravian-Silesian Region, Czechia

BivaLirudin versUS Heparin in Extracorporeal Membrane Oxygenation

Phase 2

Recruiting

Conditions: Extracorporeal Membrane Oxygenation Complication

Interventions: Drug: Unfractionated heparin
Drug: Bivalirudin

First Posted Date: 2023-07-25

Last Posted Date: 2024-08-13

Lead Sponsor: Sydney Local Health District

Target Recruit Count: 80

Registration Number: NCT05959252

Locations: 🇦🇺
Royal Prince Alfred Hospital, Sydney, New South Wales, Australia

Nebulized Heparin for Prevention of Acute Lung Injury in Smoke Inhalation Injury

Phase 3

Completed

Conditions: Smoke Inhalation Injury
Acute Lung Injury

Interventions: Drug: Heparin
Other: Normal Saline

First Posted Date: 2023-06-02

Last Posted Date: 2024-12-12

Lead Sponsor: Ain Shams University

Target Recruit Count: 88

Registration Number: NCT05886998

Locations: 🇪🇬
Ain Shams University Hospitals, Cairo, Egypt

AntiThrombotic Therapy to Ameliorate Clinical Complications in Community Acquired Pneumonia

Phase 3

Recruiting

Conditions: Community-acquired Pneumonia

Interventions: Drug: Heparin

First Posted Date: 2023-05-08

Last Posted Date: 2024-11-21

Lead Sponsor: University of Manitoba

Target Recruit Count: 4000

Registration Number: NCT05848713

Locations: 🇺🇸
University of Chicago, Chicago, Illinois, United States
🇺🇸
Ochsner Clinic, Jefferson, Louisiana, United States
🇺🇸
Maine Medical Centre, Portland, Maine, United States

and more 63 locations

Effect of Different Heparinization Schemes on Prognosis of Intracranial Aneurysm

Not Applicable

Recruiting

Conditions: Intracranial Aneurysm

Interventions: Drug: Heparin sodium

First Posted Date: 2023-03-01

Last Posted Date: 2023-12-22

Lead Sponsor: The First Affiliated Hospital with Nanjing Medical University

Target Recruit Count: 90

Registration Number: NCT05749393

Locations: 🇨🇳
Jiangsu Province Hospital, Nanjing, China

Safety and Efficacy Study of VNX001 Compared to Its Individual Components (Lidocaine and Heparin) or Placebo in Subjects With IC/BPS

Phase 2

Recruiting

Conditions: Bladder Pain Syndrome
Interstitial Cystitis

Interventions: Drug: VNX001
Drug: Placebo
Drug: Heparin
Drug: Lidocaine

First Posted Date: 2023-02-21

Last Posted Date: 2024-11-20

Lead Sponsor: Vaneltix Pharma, Inc.

Target Recruit Count: 120

Registration Number: NCT05737121

Locations: 🇺🇸
IC Study LLC, Escondido, California, United States
🇺🇸
University of California Los Angeles Center for Women's Pelvic Health, Los Angeles, California, United States
🇺🇸
The Continence Center Medical Group, Inc dba Southern California Continence Center, Newport Beach, California, United States

and more 8 locations