Hydrocortisone
- Generic Name
- Hydrocortisone
- Brand Names
- Ala-cort, Ala-scalp, Alcortin, Alkindi, Anusol HC, Aquanil HC, Casporyn HC, Cipro, Cipro HC, Colocort, Cortaid, Cortane-B, Cortef, Cortenema, Cortisporin, Cortizone-10, Dermacort, Dermarest Eczema, Dermazene, Home Papkit, Hydroskin, Monistat Itch Relief, Neosporin Eczema, Preparation H Hydrocortisone, Procto-med, Procto-pak, Proctocort, Proctol, Proctosedyl, Proctosol, Proctozone HC, Scalpicin Itch Relief, Texacort, Vanoxide-HC, Xerese, Plenadren, Efmody
- Drug Type
- Small Molecule
- Chemical Formula
- C21H30O5
- CAS Number
- 50-23-7
- Unique Ingredient Identifier
- WI4X0X7BPJ
- Background
Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions. It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone.
Hydrocortisone was granted FDA approval on 5 August 1952.
- Indication
Otic solutions are indicated for infections of the external auditory canal caused by susceptible organisms and with inflammation. Hydrocortisone tablets are indicated for certain endocrine, rheumatic, collagen, allergic, ophthalmic, respiratory, hematologic, neoplastic, edematous, gastrointestinal, and other conditions. A hydrocortisone enema is indicated fo...
- Associated Conditions
- Acute Gouty Arthritis, Acute Leukemia, Acute Otitis Externa, Adrenal Insufficiency, Allergic Conjunctivitis (AC), Allergic Rhinitis (AR), Allergic corneal marginal ulcers, Ankylosing Spondylitis (AS), Aspiration Pneumonitis, Asthma, Atopic Dermatitis, Berylliosis, Bullous dermatitis herpetiformis, Chorioretinitis, Choroiditis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Contact Dermatitis, Crohn's Disease (CD), Dermatitis, Dermatomyositis (DM), Dermatosis, Drug hypersensitivity reaction, Epicondylitis, Erythroblastopenia, Fissure;Anal, Haemorrhoids, Herpes Labialis, Hypercalcemia of Malignancy, Immune Thrombocytopenia (ITP), Infection of the Fenestration Cavity, Infection of the Mastoidectomy Cavity, Iridocyclitis, Iritis, Itching caused by Hemorrhoids, Itching of the Anus, Keratitis, Leukemias, Loeffler's syndrome, Lymphoma, Lymphomas NEC, Mycosis Fungoides (MF), Ophthalmia, Sympathetic, Optic Neuritis, Pain caused by Hemorrhoids, Pemphigus, Posterior Uveitis, Posttraumatic Osteoarthritis, Primary adrenocortical insufficiency, Proctitis, Proteinuria, Pruritis of the skin, Psoriatic Arthritis, Rectal inflammations NEC, Rheumatic heart disease, unspecified, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Secondary adrenocortical insufficiency, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Skin Diseases, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Acquired immune hemolytic anemia, Acute Bursitis, Acute Tenosynovitis, Acute rheumatic carditis, Anterior eye segment inflammation, Cryptitis, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Fulminating Pulmonary Tuberculosis, Non-suppurative Thyroiditis, Severe Erythema multiforme, Severe Psoriasis, Subacute Bursitis, Superficial infection of the external auditory canal with inflammation, Symptomatic Sarcoidosis, Systemic Dermatomyositis, Varicella-zoster virus acute retinal necrosis
- Associated Therapies
- Palliative Treatment
177Lu Radiolabeled Monoclonal Antibody HuJ591 (177Lu-J591) and Ketoconazole in Patients With Prostate Cancer
- Conditions
- Interventions
- First Posted Date
- 2009-03-11
- Last Posted Date
- 2024-05-24
- Lead Sponsor
- Weill Medical College of Cornell University
- Target Recruit Count
- 55
- Registration Number
- NCT00859781
- Locations
- 🇺🇸
Weill Cornell Medical College, New York, New York, United States
🇺🇸The University of Kansas Cancer Center, Westwood, Kansas, United States
🇺🇸USC/Norris Comprehensive cancer center, Los Angeles, California, United States
Efficacy of Single Dose IV Hydrocortisone in Post Traumatic Stress Disorder (PTSD) Prevention
- Conditions
- Interventions
- First Posted Date
- 2009-03-04
- Last Posted Date
- 2016-05-24
- Lead Sponsor
- Sheba Medical Center
- Target Recruit Count
- 120
- Registration Number
- NCT00855270
- Locations
- 🇮🇱
Sheba Medical Center, Ramat-Gan, Israel
Treatment of High Risk Adult Acute Lymphoblastic Leukemia
- Conditions
- First Posted Date
- 2009-02-27
- Last Posted Date
- 2020-04-07
- Lead Sponsor
- PETHEMA Foundation
- Target Recruit Count
- 100
- Registration Number
- NCT00853008
- Locations
- 🇪🇸
Hospital Germans Trias i Pujol, Badalona, Spain
🇪🇸Clínica Teknon, Barcelona, Spain
🇪🇸Hospital de Fuenlabrada, Madrid, Spain
Effect of Treatment With Stress-Doses Glucocorticoid in Patients With Acute Respiratory Distress Syndrome (ARDS)
- Conditions
- Interventions
- First Posted Date
- 2008-10-16
- Last Posted Date
- 2009-02-18
- Lead Sponsor
- Southeast University, China
- Target Recruit Count
- 100
- Registration Number
- NCT00773058
Cortisol Augmentation of Prolonged Exposure Therapy
- Conditions
- Interventions
- First Posted Date
- 2008-09-12
- Last Posted Date
- 2012-07-27
- Target Recruit Count
- 11
- Registration Number
- NCT00751855
- Locations
- 🇺🇸
James J. Peters Veterans Affairs Medical Center, Bronx, New York, United States
Evaluation of Corticosteroid Therapy in Childhood Severe Sepsis - a Randomised Pilot Study
- First Posted Date
- 2008-08-11
- Last Posted Date
- 2016-05-06
- Target Recruit Count
- 21
- Registration Number
- NCT00732277
- Locations
- 🇬🇧
Bristol Royal Hospital for Children, Bristol, UK, United Kingdom
🇬🇧Imperial College Healthcare NHS Trust, London, UK, United Kingdom
🇬🇧Southampton University Hospitals NHS Trust, Southampton, UK, United Kingdom
Rapid Effects of Hydrocortisone on Glucose-induced Insulin Secretion in Healthy Humans
- Conditions
- First Posted Date
- 2008-07-03
- Last Posted Date
- 2011-06-01
- Lead Sponsor
- Medical University of Vienna
- Target Recruit Count
- 10
- Registration Number
- NCT00709839
- Locations
- 🇦🇹
Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria
Trial of Hydrocortisone for Post-Traumatic Stress Disorder (PTSD)
- Conditions
- Interventions
- First Posted Date
- 2008-06-27
- Last Posted Date
- 2015-06-03
- Lead Sponsor
- University of California, San Diego
- Registration Number
- NCT00706173
- Locations
- 🇺🇸
University of California, San Diego, La Jolla, California, United States
Efficacy and Safety of Calcipotriol Plus Hydrocortisone Ointment in Psoriasis Vulgaris on the Face and Skin Folds
- Conditions
- Interventions
- First Posted Date
- 2008-06-05
- Last Posted Date
- 2021-08-26
- Lead Sponsor
- LEO Pharma
- Target Recruit Count
- 1245
- Registration Number
- NCT00691002
- Locations
- 🇵🇱
Latvia - managed by CRO, Warszawa, Poland
🇷🇸Serbia - managed by CRO, New Belgrade, Serbia
🇵🇱Hungary - managed by CRO, Warszawa, Poland
The Hypothalamic-Pituitary-Adrenal (HPA) Axis as an Effector System in Weight Regulation
- Conditions
- Interventions
- First Posted Date
- 2008-06-03
- Last Posted Date
- 2008-06-05
- Lead Sponsor
- Oregon Health and Science University
- Target Recruit Count
- 24
- Registration Number
- NCT00688987
- Locations
- 🇺🇸
Oregon Health & Science University, Portland, Oregon, United States
Drug Development Updates
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