Hydrocortisone

Generic Name: Hydrocortisone

Brand Names: Ala-cort, Ala-scalp, Alcortin, Alkindi, Anusol HC, Aquanil HC, Casporyn HC, Cipro, Cipro HC, Colocort, Cortaid, Cortane-B, Cortef, Cortenema, Cortisporin, Cortizone-10, Dermacort, Dermarest Eczema, Dermazene, Home Papkit, Hydroskin, Monistat Itch Relief, Neosporin Eczema, Preparation H Hydrocortisone, Procto-med, Procto-pak, Proctocort, Proctol, Proctosedyl, Proctosol, Proctozone HC, Scalpicin Itch Relief, Texacort, Vanoxide-HC, Xerese, Plenadren, Efmody

Drug Type: Small Molecule

Chemical Formula: C_₂₁H_₃₀O_₅

CAS Number: 50-23-7

Unique Ingredient Identifier: WI4X0X7BPJ

Background: Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions. It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone.

Hydrocortisone was granted FDA approval on 5 August 1952.

Indication: Otic solutions are indicated for infections of the external auditory canal caused by susceptible organisms and with inflammation. Hydrocortisone tablets are indicated for certain endocrine, rheumatic, collagen, allergic, ophthalmic, respiratory, hematologic, neoplastic, edematous, gastrointestinal, and other conditions. A hydrocortisone enema is indicated fo...

Associated Conditions: Acute Gouty Arthritis, Acute Leukemia, Acute Otitis Externa, Adrenal Insufficiency, Allergic Conjunctivitis (AC), Allergic Rhinitis (AR), Allergic corneal marginal ulcers, Ankylosing Spondylitis (AS), Aspiration Pneumonitis, Asthma, Atopic Dermatitis, Berylliosis, Bullous dermatitis herpetiformis, Chorioretinitis, Choroiditis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Contact Dermatitis, Crohn's Disease (CD), Dermatitis, Dermatomyositis (DM), Dermatosis, Drug hypersensitivity reaction, Epicondylitis, Erythroblastopenia, Fissure;Anal, Haemorrhoids, Herpes Labialis, Hypercalcemia of Malignancy, Immune Thrombocytopenia (ITP), Infection of the Fenestration Cavity, Infection of the Mastoidectomy Cavity, Iridocyclitis, Iritis, Itching caused by Hemorrhoids, Itching of the Anus, Keratitis, Leukemias, Loeffler's syndrome, Lymphoma, Lymphomas NEC, Mycosis Fungoides (MF), Ophthalmia, Sympathetic, Optic Neuritis, Pain caused by Hemorrhoids, Pemphigus, Posterior Uveitis, Posttraumatic Osteoarthritis, Primary adrenocortical insufficiency, Proctitis, Proteinuria, Pruritis of the skin, Psoriatic Arthritis, Rectal inflammations NEC, Rheumatic heart disease, unspecified, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Secondary adrenocortical insufficiency, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Skin Diseases, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Acquired immune hemolytic anemia, Acute Bursitis, Acute Tenosynovitis, Acute rheumatic carditis, Anterior eye segment inflammation, Cryptitis, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Fulminating Pulmonary Tuberculosis, Non-suppurative Thyroiditis, Severe Erythema multiforme, Severe Psoriasis, Subacute Bursitis, Superficial infection of the external auditory canal with inflammation, Symptomatic Sarcoidosis, Systemic Dermatomyositis, Varicella-zoster virus acute retinal necrosis

Associated Therapies: Palliative Treatment

Clinical Trials

The Effect of Glucocorticoid Therapy on Left Ventricular Remodelling in Acute Myocardial Infarction (RECONSIDER)

Phase 2

Conditions: ST-segment Elevation Myocardial Infarction
Left Ventricular Remodeling

Interventions: Drug: Placebo
Drug: Hydrocortisone

First Posted Date: 2017-12-13

Last Posted Date: 2020-09-28

Lead Sponsor: Iuliu Hatieganu University of Medicine and Pharmacy

Target Recruit Count: 77

Registration Number: NCT03371784

Locations: 🇷🇴
"Niculae Stancioiu" Heart Institute, Cluj-Napoca, Cluj, Romania

Pevonedistat With VXLD Chemotherapy for Adolescent/Young Adults With Relapsed/Refractory ALL or Lymphoblastic NHL

Phase 1

Completed

Conditions: Refractory Acute Lymphoblastic Leukemia
Relapsed Acute Lymphoblastic Leukemia

Interventions: Drug: Pevonedistat
Drug: Vincristine
Drug: Dexamethasone
Drug: PEG-asparaginase
Drug: Doxorubicin
Drug: Cytarabine
Drug: Methotrexate
Drug: Hydrocortisone

First Posted Date: 2017-11-21

Last Posted Date: 2022-10-20

Lead Sponsor: Julio Barredo, MD

Target Recruit Count: 6

Registration Number: NCT03349281

Locations: 🇺🇸
University of Miami, Miami, Florida, United States

The Effect of Vitamin C, Thiamine and Hydrocortisone on Clinical Course and Outcome in Patients With Severe Sepsis and Septic Shock

Phase 4

Terminated

Conditions: Sepsis
Fluid Overload
Septic Shock
Critical Illness

Interventions: Drug: 0.9% Sodium Chloride Injection
Drug: Vitamin C
Drug: Hydrocortisone
Drug: Thiamine

First Posted Date: 2017-11-07

Last Posted Date: 2019-02-19

Lead Sponsor: University Medical Centre Ljubljana

Target Recruit Count: 5

Registration Number: NCT03335124

Locations: 🇸🇮
Department of Gastroenterology, UMC Ljubljana, Ljubljana, Slovenia

CRF - Nociceptin Receptor Interactions

Early Phase 1

Completed

Conditions: Healthy

Interventions: Drug: Hydrocortisone
Radiation: [C-11]NOP-1A

First Posted Date: 2017-10-05

Last Posted Date: 2020-10-27

Lead Sponsor: University of Pittsburgh

Target Recruit Count: 19

Registration Number: NCT03302416

Locations: 🇺🇸
University of Pittsburgh, Pittsburgh, Pennsylvania, United States

ASIA Down Syndrome Acute Lymphoblastic Leukemia 2016

Phase 2

Recruiting

Conditions: Childhood Cancer
Acute Lymphoblastic Leukemia
Down Syndrome

Interventions: Drug: Daunorubicin
Drug: Prednisolone
Drug: Vincristine
Drug: Epirubicin
Drug: E-coli L-asparaginase
Drug: 6-Mercaptopurine
Drug: Methotrexate
Drug: Hydrocortisone
Drug: Cytarabine
Drug: Cyclophosphamide

First Posted Date: 2017-09-18

Last Posted Date: 2022-09-28

Lead Sponsor: National Hospital Organization Nagoya Medical Center

Target Recruit Count: 60

Registration Number: NCT03286634

Locations: 🇯🇵
Kagoshima University Hospital, Kagoshima, Japan
🇲🇾
University of Malaya Medical Centre, Kuala Lumpur, Malaysia
🇲🇾
Subang Jaya Medical Centre, Subang Jaya, Malaysia

and more 7 locations

Effects of Glucocorticoids on Cognition in HIV-infected Women

Early Phase 1

Completed

Conditions: Hiv

Interventions: Drug: Placebo Oral Tablet
Drug: Hydrocortisone

First Posted Date: 2017-08-02

Last Posted Date: 2023-09-29

Lead Sponsor: Johns Hopkins University

Target Recruit Count: 136

Registration Number: NCT03237689

Locations: 🇺🇸
Johns Hopkins University School of Medicine, Baltimore, Maryland, United States

A Study of the Efficacy, Safety and Tolerability of Chronocort in Treating CAH

Phase 3

Completed

Conditions: Congenital Adrenal Hyperplasia

Interventions: Drug: Hydrocortisone

First Posted Date: 2017-02-23

Last Posted Date: 2024-10-28

Lead Sponsor: Diurnal Limited

Target Recruit Count: 91

Registration Number: NCT03062280

Locations: 🇺🇸
National Institutes of Health Clinical Center, Bethesda, Maryland, United States

Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Children and Adolescents

Phase 3

Active, not recruiting

Conditions: Acute Lymphoblastic Leukemia, Pediatric

Interventions: Drug: Pegaspargase
Drug: Erwinia asparaginase
Drug: Cyclophosphamide
Drug: DEXAMETHASONE
Drug: CYTARABINE
Drug: DASATINIB
Drug: LEUCOVORIN CALCIUM
Drug: Dexrazoxane
Drug: Doxorubicin
Drug: MERCAPTOPURINE
Drug: METHOTREXATE
Drug: ETOPOSIDE
Drug: HYDROCORTISONE
Drug: Vincristine
Drug: NELARABINE

First Posted Date: 2017-01-13

Last Posted Date: 2024-08-15

Lead Sponsor: Dana-Farber Cancer Institute

Target Recruit Count: 560

Registration Number: NCT03020030

Locations: 🇺🇸
Dana-Farber Cancer Institute, Boston, Massachusetts, United States
🇺🇸
Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, United States
🇨🇦
Hospital Sainte Justine, University of Montreal, Montreal, Quebec, Canada

and more 6 locations