Pentoxyverine
- Generic Name
- Pentoxyverine
- Drug Type
- Small Molecule
- Chemical Formula
- C20H31NO3
- CAS Number
- 77-23-6
- Unique Ingredient Identifier
- 32C726X12W
Overview
Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma-1 receptors, as well as kappa and mu-opioid receptors. The FDA withdrew the use of all oral gel drug products containing pentoxyverine citrate. Other forms of pentoxyverine citrate continue to be marketed.
Background
Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma-1 receptors, as well as kappa and mu-opioid receptors. The FDA withdrew the use of all oral gel drug products containing pentoxyverine citrate. Other forms of pentoxyverine citrate continue to be marketed.
Indication
Indicated as a cough suppressant to relieve cough caused by the common cold, flu, bronchitis, and sinusitis .
Associated Conditions
- Bronchial irritation
- Cough
- Throat irritation
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2014/07/08 | Phase 1 | Completed |
FDA Approved Products
Product Name | Manufacturer | Route | Strength | Approved | NDC Code |
|---|
No FDA products found
No FDA products found for this drug
EMA Approved Products
Medicine Name | EMA Number | Auth. Holder | Country | Drug Type | Status | Issued | Opinion | Revision |
|---|
No EMA products found
No EMA products found for this drug
HSA Approved Products
Product Name | Manufacturer | Dosage Form | Strength | Approved | Approval No. |
|---|
No HSA products found
No HSA products found for this drug
NMPA Approved Products
Product Name | Approval No. | Manufacturer | Dosage Form | Trade Name | Strength | Type | Status | Date | Import |
|---|---|---|---|---|---|---|---|---|---|
国药准字H36022036 | 糖浆剂 | N/A | 0.25% | Chemical Drug | Approved | 2020/11/04 | Domestic | ||
国药准字H23023068 | 糖浆剂 | N/A | 0.25％ | Chemical Drug | Approved | 2015/09/25 | Domestic | ||
国药准字H37023403 | N/A | N/A | 复方 | Chemical Drug | Approved | 2002/12/18 | Domestic | ||
国药准字H32026079 | N/A | N/A | 0.25% | Chemical Drug | Approved | 2003/03/25 | Domestic | ||
国药准字H53021780 | 糖浆剂 | N/A | 0.25% | Chemical Drug | Approved | 2020/06/15 | Domestic | ||
国药准字H31022520 | N/A | N/A | 0.25% | Chemical Drug | Approved | 2003/03/25 | Domestic | ||
国药准字H20053336 | 糖浆剂 | N/A | 0.25% | Chemical Drug | Approved | 2019/12/06 | Domestic | ||
国药准字H15021469 | 糖浆剂 | N/A | 复方 | Chemical Drug | Approved | 2020/04/02 | Domestic | ||
国药准字H32026055 | N/A | N/A | 0.25% | Chemical Drug | Approved | 2003/03/25 | Domestic | ||
国药准字H44024309 | 糖浆剂 | N/A | 0.25% | Chemical Drug | Approved | 2015/06/01 | Domestic |
PPB Approved Products
Product Name | Registration Code | Company | Category | Sale Type | Reg. Date |
|---|---|---|---|---|---|
HK-48259 | unicorn laboratories o/b american unicorn laboratories limited | Part 2 Poison | OTC | 2001/07/28 | |
HK-59365 | karen laboratories o/b karen pharmaceutical co ltd | Part 2 Poison | OTC | 2010/03/08 | |
HK-48456 | unicorn laboratories o/b american unicorn laboratories limited | Part 2 Poison | OTC | 2001/09/19 | |
HK-55565 | vickmans laboratories ltd | Part 2 Poison | OTC | 2007/04/30 | |
HK-56323 | synco (h.k.) limited | Part 2 Poison | OTC | 2008/02/15 | |
HK-53574 | vickmans laboratories ltd | Part 2 Poison | OTC | 2005/08/13 | |
HK-55806 | europharm lab co ltd | Part 2 Poison | OTC | 2007/08/05 | |
HK-43070 | vickmans laboratories ltd | Part 2 Poison | OTC | 1998/05/21 | |
HK-55466 | vickmans laboratories ltd | Part 2 Poison | OTC | 2007/03/25 | |
HK-54521 | vickmans laboratories ltd | Part 2 Poison | OTC | 2006/07/15 |
TGA Approved Products
Product Name | ARTG ID | Sponsor | Status | Reg. Date | Ingredient |
|---|---|---|---|---|---|
52355 | Active | 1995/05/11 | pentoxyverine citrate |