Memantine

Generic Name
Memantine
Brand Names
Axura, Ebixa, Marixino, Namenda, Namenda 49 Titration Pack, Namzaric, Nemdatine, Memantine Mylan, Memantine ratiopharm, Memantine Merz, Marixino (previously Maruxa), Memantine Accord, Memantine LEK
Drug Type
Small Molecule
Chemical Formula
C12H21N
CAS Number
19982-08-2
Unique Ingredient Identifier
W8O17SJF3T
Background

Initially approved by the FDA in 2013, memantine is an N-methyl-D-aspartate (NMDA) receptor antagonist used in the management of Alzheimer's Disease (AD). It is different from many other Alzheimer's Disease medications, as it works by a different mechanism than the cholinesterase enzyme inhibitors normally employed in the management of Alzheimer's disease . ...

Indication

Memantine is used to manage moderate to severe Alzheimer's dementia .
...

Associated Conditions
Alzheimer's Disease (AD), Moderate to Severe Alzheimer's Disease, Mild Vascular dementia, Moderate Alzheimer's Type Dementia, Moderate Vascular dementia, Severe Alzheimer's Type Dementia
Associated Therapies
-
Clinical Trials
Related News

Memantine in Bipolar Patients With Alcoholism

Phase 3
Conditions
AOD Effects and Consequences
Interventions
Drug: Memantine
First Posted Date
2017-02-03
Last Posted Date
2017-10-03
Lead Sponsor
National Cheng-Kung University Hospital
Target Recruit Count
60
Registration Number
NCT03043001
Locations
🇨🇳

National Cheng Kung University Hospital, Tainan, Taiwan

Combination of Dextromethorphan and Memantine in Treating Bipolar Disorder

First Posted Date
2017-02-01
Last Posted Date
2017-07-11
Lead Sponsor
National Cheng-Kung University Hospital
Target Recruit Count
300
Registration Number
NCT03039842
Locations
🇨🇳

National Cheng Kung University Hospital, Tainan, Taiwan

Predicting Treatment Response to Memantine in Autism Using Magnetic Resonance Spectroscopy

First Posted Date
2016-06-23
Last Posted Date
2021-04-14
Lead Sponsor
University of Missouri-Columbia
Target Recruit Count
10
Registration Number
NCT02811627
Locations
🇺🇸

University of Missouri, Columbia, Missouri, United States

Efficacy of Memantine add-on in the Treatment of Bipolar Disorder (Type I) Nonresponders or Partial Responders Patients

Phase 2
Conditions
Bipolar Disorder
Interventions
Drug: Placebo
Drug: Memantine
First Posted Date
2015-12-15
Last Posted Date
2019-10-03
Lead Sponsor
University of Sao Paulo
Target Recruit Count
44
Registration Number
NCT02630888
Locations
🇧🇷

Institute of Psychiatry, University of Sao Paulo, Sao Paulo, Brazil

SUVN-502 With Donepezil and Memantine for the Treatment of Moderate Alzheimer's Disease- Phase 2a Study

First Posted Date
2015-10-20
Last Posted Date
2023-06-09
Lead Sponsor
Suven Life Sciences Limited
Target Recruit Count
564
Registration Number
NCT02580305
Locations
🇺🇸

Senior Clinical Trials, Inc., Laguna Hills, California, United States

🇺🇸

Emerald Coast Center for Neurological Disorders, Pensacola, Florida, United States

🇺🇸

Neurological Associates of Albany, PC, Albany, New York, United States

and more 67 locations

Evaluation of Memantine Versus Placebo on Ischemic Stroke Outcome

First Posted Date
2015-08-28
Last Posted Date
2020-10-06
Lead Sponsor
Mazandaran University of Medical Sciences
Target Recruit Count
47
Registration Number
NCT02535611

Treatment of Pendular Nystagmus in OPT

First Posted Date
2015-06-09
Last Posted Date
2018-07-11
Lead Sponsor
Hospices Civils de Lyon
Target Recruit Count
7
Registration Number
NCT02466191
Locations
🇫🇷

Hospices Civils de Lyon, Lyon, France

Pharmacovigilance in Gerontopsychiatric Patients

Phase 3
Terminated
Conditions
Dementia
Depression
Schizophrenia
Psychosomatic Disorders
Anxiety Disorders
Interventions
Drug: Phenobarbital
Drug: Phenytoin
Drug: Carbamazepine
Drug: Oxcarbazepine
Drug: Valproic Acid
Drug: Lamotrigine
Drug: Topiramate
Drug: Gabapentin
Drug: Levetiracetam
Drug: Pregabalin
Drug: Lacosamide
Drug: Clonazepam
Drug: Biperiden
Drug: Levomepromazine
Drug: Fluphenazine
Drug: Perphenazine
Drug: Perazine
Drug: Thioridazine
Drug: Haloperidol
Drug: Melperone
Drug: Pipamperone
Drug: Bromperidol
Drug: Benperidol
Drug: Sertindole
Drug: Ziprasidone
Drug: Flupentixol
Drug: Chlorprothixene
Drug: Zuclopenthixol
Drug: Fluspirilene
Drug: Pimozide
Drug: Clozapine
Drug: Olanzapine
Drug: Quetiapine
Drug: Sulpiride
Drug: Tiapride
Drug: Amisulpride
Drug: Prothipendyl
Drug: Risperidone
Drug: Aripiprazole
Drug: Paliperidone
Drug: Diazepam
Drug: Oxazepam
Drug: Lorazepam
Drug: Bromazepam
Drug: Clobazam
Drug: Alprazolam
Drug: Hydroxyzine
Drug: Buspirone
Drug: Chloral Hydrate
Drug: Flurazepam
Drug: Nitrazepam
Drug: Triazolam
Drug: Lormetazepam
Drug: Temazepam
Drug: Midazolam
Drug: Brotizolam
Drug: Zopiclone
Drug: Zolpidem
Drug: Zaleplon
Drug: Melatonin
Drug: Clomethiazole
Drug: Diphenhydramine
Drug: Promethazine
Drug: Imipramine
Drug: Clomipramine
Drug: Opipramol
Drug: Trimipramine
Drug: Amitriptyline
Drug: Nortriptyline
Drug: Doxepin
Drug: Maprotiline
Drug: Amitriptyline oxide
Drug: Fluoxetine
Drug: Citalopram
Drug: Paroxetine
Drug: Sertraline
Drug: Fluvoxamine
Drug: Escitalopram
Drug: Tranylcypromine
Drug: Moclobemide
Drug: Mianserin
Drug: Trazodone
Drug: Mirtazapine
Drug: Bupropion
Drug: Venlafaxine
Drug: Reboxetine
Drug: Duloxetine
Drug: Agomelatine
Drug: Pyritinol
Drug: Piracetam
Drug: Donepezil
Drug: Rivastigmine
Drug: Galantamine
Drug: Memantine
Drug: Nicergoline
Drug: Acamprosate
Drug: Lithium
First Posted Date
2015-03-02
Last Posted Date
2018-02-28
Lead Sponsor
Hannover Medical School
Target Recruit Count
407
Registration Number
NCT02374567
Locations
🇩🇪

Bezirkskrankenhaus Augsburg, Augsburg, Germany

🇩🇪

Krankenhaus Hedwigshöhe, Berlin, Germany

🇩🇪

Hannover Medical School, Hannover, Germany

and more 2 locations

Memantine Hydrochloride and Whole-Brain Radiotherapy With or Without Hippocampal Avoidance in Reducing Neurocognitive Decline in Patients With Brain Metastases

First Posted Date
2015-02-10
Last Posted Date
2024-11-26
Lead Sponsor
NRG Oncology
Target Recruit Count
518
Registration Number
NCT02360215
Locations
🇺🇸

Los Angeles County-USC Medical Center, Los Angeles, California, United States

🇺🇸

USC / Norris Comprehensive Cancer Center, Los Angeles, California, United States

🇺🇸

Marshfield Clinic Stevens Point Center, Stevens Point, Wisconsin, United States

and more 217 locations

Down Syndrome Memantine Follow-up Study

First Posted Date
2014-12-01
Last Posted Date
2023-06-27
Lead Sponsor
University Hospitals Cleveland Medical Center
Target Recruit Count
160
Registration Number
NCT02304302
Locations
🇺🇸

University Hospitals Case Medical Center, Cleveland, Ohio, United States

🇧🇷

Sociedade Beneficente Israelita Brasileira Albert Einstein, São Paulo, SP, Brazil

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