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概览

Amsacrine is a cytotoxic agent used to induce remission in acute adult leukemia that is not adequately responsive to other agents.

作用机制

Amsacrine binds to DNA through intercalation and external binding. It has a base specificity for A-T pairs. Rapidly dividing cells are two to four times more sensitive to amsacrine than are resting cells. Amsacrine appears to cleave DNA by inducing double stranded breaks. Amsacrine also targets and inhibits topoisomerase II. Cytotoxicity is greatest during the S phase of the cell cycle when topoisomerase levels are at a maximum.

适应症

For treatment of acute myeloid leukaemia.

• Refractory Leukemia