Ganciclovir
- Generic Name
- Ganciclovir
- Brand Names
- Cytovene, Zirgan
- Drug Type
- Small Molecule
- Chemical Formula
- C9H13N5O4
- CAS Number
- 82410-32-0
- Unique Ingredient Identifier
- P9G3CKZ4P5
- Background
An acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.
- Indication
For induction and maintenance in the treatment of cytomegalovirus (CMV) retinitis in immunocompromised patients, including patients with acquired immunodeficiency syndrome (AIDS). Also used in the treatment of severe cytomegalovirus (CMV) disease, including CMV pneumonia, CMV gastrointestinal disease, and disseminated CMV infections, in immunocompromised pat...
- Associated Conditions
- CMV colitis, Cytomegalovirus (CMV) Infections, Cytomegalovirus Retinitis, Cytomegalovirus gastroesophagitis, Varicella-zoster Progressive outer retinal necrosis, Acute Herpetic keratitis, Cytomegalovirus neurological disease, Varicella-zoster virus acute retinal necrosis
- Associated Therapies
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Could mosquitoes deliver vaccines against malaria?
Researchers from Leiden University Medical Center and Radboud University engineered mosquitoes to deliver vaccines, potentially enhancing immunity against malaria. The vaccine uses a weakened Plasmodium falciparum parasite, which does not cause disease symptoms. Trials showed 13% and 89% immunity in GA1 and GA2 groups, respectively. Further research is needed for larger-scale testing and protection against different malaria strains.
New malaria vaccine shows high protection in clinical trial
A late-liver-stage attenuated malaria parasite vaccine, GA2, demonstrated promising safety and efficacy in a clinical trial, inducing a favorable immune response and providing 89% protective efficacy against malaria infection.
Drug Development Updates
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