Ganciclovir
- Generic Name
- Ganciclovir
- Brand Names
- Cytovene, Zirgan
- Drug Type
- Small Molecule
- Chemical Formula
- C9H13N5O4
- CAS Number
- 82410-32-0
- Unique Ingredient Identifier
- P9G3CKZ4P5
- Background
An acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.
- Indication
For induction and maintenance in the treatment of cytomegalovirus (CMV) retinitis in immunocompromised patients, including patients with acquired immunodeficiency syndrome (AIDS). Also used in the treatment of severe cytomegalovirus (CMV) disease, including CMV pneumonia, CMV gastrointestinal disease, and disseminated CMV infections, in immunocompromised pat...
- Associated Conditions
- CMV colitis, Cytomegalovirus (CMV) Infections, Cytomegalovirus Retinitis, Cytomegalovirus gastroesophagitis, Varicella-zoster Progressive outer retinal necrosis, Acute Herpetic keratitis, Cytomegalovirus neurological disease, Varicella-zoster virus acute retinal necrosis
- Associated Therapies
- -
Islet Transplantation for Type 1 Diabetes
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2017-03-15
- Target Recruit Count
- 36
- Registration Number
- NCT00014911
- Locations
- 🇩🇪
Justus-Leibig University, Giessen, Germany
🇨🇦University of Alberta, Edmonton, Alberta, Canada
🇨🇭University of Geneva, Geneva, Switzerland
A Randomized Comparative Pharmacokinetic Study of Oral Ganciclovir After Treatment With Intravenous Ganciclovir for Cytomegalovirus Gastrointestinal Disease in AIDS Patients
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-04
- Target Recruit Count
- 24
- Registration Number
- NCT00000768
- Locations
- 🇺🇸
Alabama Therapeutics CRS, Birmingham, Alabama, United States
🇺🇸Washington U CRS, Saint Louis, Missouri, United States
🇺🇸Univ. of Cincinnati CRS, Cincinnati, Ohio, United States
A Study of Foscarnet Plus Ganciclovir in the Treatment of Cytomegalovirus of the Eye in Patients With AIDS Who Have Already Been Treated With Ganciclovir
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-04
- Target Recruit Count
- 30
- Registration Number
- NCT00000970
- Locations
- 🇺🇸
Ucsf Aids Crs, San Francisco, California, United States
🇺🇸USC CRS, Los Angeles, California, United States
🇺🇸Washington U CRS, Saint Louis, Missouri, United States
A Study of AZT Plus Ganciclovir in Patients With AIDS and Cytomegalovirus (CMV) Infection
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-04
- Target Recruit Count
- 60
- Registration Number
- NCT00000995
- Locations
- 🇺🇸
Bellevue Hosp / New York Univ Med Ctr, New York, New York, United States
🇺🇸Univ of California / San Diego Treatment Ctr, San Diego, California, United States
🇺🇸Univ of Rochester Medical Center, Rochester, New York, United States
The Safety and Effectiveness of Ganciclovir in the Prevention of Cytomegalovirus (CMV) of the Eyes and Disease of the Stomach and Intestines in Patients With HIV
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-04
- Target Recruit Count
- 850
- Registration Number
- NCT00001034
- Locations
- 🇺🇸
Community Consortium of San Francisco, San Francisco, California, United States
🇺🇸Denver CPCRA / Denver Public Hlth, Denver, Colorado, United States
🇺🇸Louisiana Comm AIDS Rsch Prog / Tulane Univ Med, New Orleans, Louisiana, United States
A Phase I/II Open-Labelled Trial of Intravitreal Ganciclovir Salvage Therapy for AIDS Patients With Active CMV Retinitis Who Are Intolerant of Systemic Therapy
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-10-27
- Target Recruit Count
- 38
- Registration Number
- NCT00000673
- Locations
- 🇺🇸
Univ. of Miami AIDS CRS, Miami, Florida, United States
🇺🇸Washington U CRS, Saint Louis, Missouri, United States
A Phase I Pharmacokinetic and Tolerance Study of 28-Day Regimens of Oral Ganciclovir
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-03
- Target Recruit Count
- 48
- Registration Number
- NCT00000668
- Locations
- 🇺🇸
San Francisco AIDS Clinic / San Francisco Gen Hosp, San Francisco, California, United States
🇺🇸Univ of California / San Diego Treatment Ctr, San Diego, California, United States
🇺🇸Cornell Univ Med Ctr, New York, New York, United States
A Comparison of Valganciclovir and Ganciclovir in the Treatment of Cytomegalovirus (CMV) of the Eyes
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2017-05-17
- Lead Sponsor
- Hoffmann-La Roche
- Registration Number
- NCT00002377
- Locations
- 🇺🇸
Univ of California / San Diego / Dept of Pediatrics, La Jolla, California, United States
🇺🇸St Luke's - Roosevelt Hosp Ctr / Div of Infect Dis, New York, New York, United States
🇺🇸New York Hosp - Cornell Med Ctr, New York, New York, United States
A Pilot Study to Obtain Preliminary Information Regarding the Efficacy and Safety of the Combination of Immune Globulin and Ganciclovir as Compared to Ganciclovir Alone in the Treatment of Sight-Threatening CMV Retinitis in Patients With AIDS
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- American National Red Cross
- Registration Number
- NCT00001999
- Locations
- 🇺🇸
Georgetown Univ Med Ctr, Washington, District of Columbia, United States
A Treatment Protocol for the Use of Intravenous Ganciclovir in AIDS Patients With Immediately Sight-Threatening CMV Retinitis
- Conditions
- Locations
- 🇺🇸
Natl Inst of Allergy & Infect Dis / Cln Ctr, Bethesda, Maryland, United States
Drug Development Updates
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