Trimethadione
生产企业：Abbott laboratories pharmaceutical products div
Trimethadione is an anticonvulsant agent indicated for the control of treatment-refractory petit mal seizures.
Trimethadione is an anticonvulsant agent indicated for the control of treatment-refractory petit mal seizures.
Dione anticonvulsants reduce T-type calcium currents in thalamic neurons, including thalamic relay neurons. It does so via the inhibition of voltage dependent T-type calcium channels. This raises the threshold for repetitive activity in the thalamus, and inhibits corticothalamic transmission. Thus, the abnormal thalamocortical rhythmicity, which is thought to underlie the 3-Hz spike-and-wave discharge seen on electroencephalogram(EEG) with absence seizures, is dampened.
对癫痫小发作疗效较好。用于治疗原发性癫痫小发作，但不作为首选药，仅在乙琥胺或苯琥胺疗效不佳时使用。本药开始作用慢，服药2～4天开始显效。
每项发明一条，涵盖美国、欧洲、PCT 与中国的同族专利。
