Hydrochlorothiazide

Generic Name: Hydrochlorothiazide

Brand Names: Accuretic, Actelsar Hct, Aldactazide, Altace HCT, Atacand, Atacand Hct, Avalide, Benicar Hct, Diovan Hct, Exforge Hct, Hyzaar, Ifirmacombi, Karvezide, Lopressor Hct, Lotensin Hct, Maxzide, Micardis-hct, Olmetec Plus, Tekturna Hct, Teveten HCT, Tribenzor, Urozide, Vaseretic, Viskazide, Zestoretic, Ziac

Drug Type: Small Molecule

Chemical Formula: C_₇H_₈ClN_₃O_₄S_₂

CAS Number: 58-93-5

Unique Ingredient Identifier: 0J48LPH2TH

Background: Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension. Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and angiotensin converting enzyme inhibitors or angiotensin II receptor blockers.

Hydrochlorothiazide was granted FDA approval on 12 February 1959.

Indication: Hydrochlorothiazide is indicated alone or in combination for the management of edema associated with congestive heart failure, hepatic cirrhosis, nephrotic syndrome, acute glomerulonephritis, chronic renal failure, and corticosteroid and estrogen therapy. Hydrochlorothiazide is also indicated alone or in combination for the management of hypertension.

Associated Conditions: Calcium Nephrolithiasis, Cirrhosis of the Liver, Congestive Heart Failure (CHF), Diabetes Insipidus, Edema, Hypertension, Hypertension, Essential Hypertension, Hypokalemia caused by diuretics, Nephrotic Syndrome, Pre-Eclampsia, Premenstrual tension with edema, Renal tubular acidosis, Sodium retention, Stroke

Associated Therapies: -

Clinical Trials

Benidipine and Hydrochlorothiazide in Fosinopril Treated Chronic Kidney Disease Patients With Hypertension

Phase 4

Conditions: Chronic Kidney Disease

Interventions: Drug: Fosinopril
Drug: Benidipine
Drug: Hydrochlorothiazide

First Posted Date: 2016-01-05

Last Posted Date: 2016-01-05

Lead Sponsor: Shanghai Changzheng Hospital

Target Recruit Count: 508

Registration Number: NCT02646397

Locations: 🇨🇳
Department of Nephrology, Shanghai Changzheng Hospital, Shanghai, Shanghai, China

RAS Peptide Profiles in Patients With Arterial Hypertension

Completed

Conditions: Essential Hypertension

Interventions: Drug: Perindopril
Drug: Olmesartan
Drug: Hydrochlorothiazide
Drug: Amlodipine

First Posted Date: 2015-05-20

Last Posted Date: 2019-02-22

Lead Sponsor: Insel Gruppe AG, University Hospital Bern

Target Recruit Count: 107

Registration Number: NCT02449811

Locations: 🇨🇭
University Hospital, Basel, Switzerland

Series of N-of-1 Crossover Trials of Antihypertensive Therapy in Adolescents With Essential Hypertension

Not Applicable

Completed

Conditions: Essential Hypertension

Interventions: Drug: Lisinopril
Drug: Amlodipine
Drug: Hydrochlorothiazide

First Posted Date: 2015-04-09

Last Posted Date: 2018-11-15

Lead Sponsor: The University of Texas Health Science Center, Houston

Target Recruit Count: 42

Registration Number: NCT02412761

Locations: 🇺🇸
University of Texas at Houston Medical School; Pediatric Nephrology and Hypertension Clinics, Houston, Texas, United States

INTERVENCION Trial

Phase 4

Conditions: Blood Pressure, High

Interventions: Drug: Hydrochlorothiazide
Drug: Amlodipine
Drug: Telmisartan

First Posted Date: 2015-02-26

Last Posted Date: 2015-10-21

Lead Sponsor: Prevencion

Target Recruit Count: 120

Registration Number: NCT02373163

Locations: 🇵🇪
Centro de Investigacion PREVENCION, Arequipa, AQP, Peru

Safety, Tolerability and Pharmacokinetics of Single Rising and Multiple Oral Doses of Telmisartan / Hydrochlorothiazide (HCTZ) in Healthy Male Volunteers

Phase 1

Completed

Conditions: Healthy

Interventions: Drug: High dose of telmisartan
Drug: Low dose of telmisartan
Drug: HCTZ

First Posted Date: 2014-10-13

Last Posted Date: 2023-12-08

Lead Sponsor: Boehringer Ingelheim

Target Recruit Count: 20

Registration Number: NCT02262780

Bioequivalence of Telmisartan/ HCTZ Fixed Dose Combination Compared With Its Monocomponents in Healthy Male Volunteers II

Phase 1

Completed

Conditions: Healthy

Interventions: Drug: Telmisartan and HCTZ
Drug: Telmisartan
Drug: HCTZ

First Posted Date: 2014-10-13

Last Posted Date: 2014-10-13

Lead Sponsor: Boehringer Ingelheim

Target Recruit Count: 68

Registration Number: NCT02262858

Telmisartan and Hydrochlorothiazide Antihypertensive Treatment Study in High Sodium Intake Population

Not Applicable

Completed

Conditions: Hypertension

Interventions: Drug: Hydrochlorothiazide
Drug: Telmisartan

First Posted Date: 2014-10-02

Last Posted Date: 2015-03-11

Lead Sponsor: The George Institute for Global Health, China

Target Recruit Count: 1410

Registration Number: NCT02255253

Locations: 🇨🇳
Chinese Traditional Medicine Hospital of Anguo, Baoding, Hebei, China
🇨🇳
Lixian chinese traditional medicine hospital, Baoding, Hebei, China
🇨🇳
People's hospital in Rongcheng, Baoding, Hebei, China

and more 11 locations