Fibrinogen human
- Generic Name
- Fibrinogen human
- Brand Names
- Artiss, Evarrest, Evicel, Fibryga, Riastap, Tachosil, Tisseel, Vistaseal
- Drug Type
- Biotech
- Chemical Formula
- -
- CAS Number
- 9001-32-5
- Unique Ingredient Identifier
- N94833051K
- Background
Fibrinogen concentrate (human) is a hematological agent. It works by replacing a certain protein in the blood that helps with blood clotting. Fibrinogen (factor I) is a soluble plasma glycoprotein with a molecular weight of about 340 kDa. It is a physiological substrate for three enzymes: plasmin, factor XIIIa and thrombin. It is indicated for the treatment of acute bleeding episodes in patients with congenital fibrinogen deficiency, including afibrinogenemia and hypofibrinogenemia.
- Indication
Human fibrinogen is used for the treatment of acute bleeding episodes in patients with congenital fibrinogen deficiency, including afibrinogenemia and hypofibrinogenemia.
In combination with thrombin, it is used indicated as an adjunct to hemostasis for mild to moderate bleeding in adults undergoing surgery when control of bleeding by standard surgical techniques (such as suture, ligature, and cautery) is ineffective or impractical.
- Associated Conditions
- Bleeding, Dura Mater Nick Cut or Tear, Surgical Bleeding, Acute bleeding episodes
- Associated Therapies
- Tissue Adhesions, Maintenance of surgical hemostasis therapy
Effectiveness of Different Fibrinogen Preparations in Restoring Clot Firmness
- Conditions
- Interventions
- First Posted Date
- 2023-03-22
- Last Posted Date
- 2024-02-28
- Lead Sponsor
- IRCCS Policlinico S. Donato
- Target Recruit Count
- 40
- Registration Number
- NCT05780125
- Locations
- 🇮🇹
IRCCS Policlinico San Donato, San Donato Milanese, MI, Italy
Effect of Prophylactic Fibrinogen Concentrate In Scoliosis Surgery
- Conditions
- Interventions
- First Posted Date
- 2022-05-26
- Last Posted Date
- 2023-03-28
- Lead Sponsor
- Brno University Hospital
- Target Recruit Count
- 32
- Registration Number
- NCT05391412
- Locations
- 🇨🇿
University Hospital Brno, Brno, Czechia
Administration of Fibrinogen Concentrate for Refractory Bleeding
- Conditions
- Interventions
- First Posted Date
- 2021-10-25
- Last Posted Date
- 2024-10-30
- Target Recruit Count
- 10
- Registration Number
- NCT05091684
- Locations
- 🇫🇷
CHU de Saint-Etienne, Saint-Étienne, France
ZEPLAST- PED: ZEro_PLASma Trial in Small Infants Undergoing Cardiac Surgery
- Conditions
- Interventions
- First Posted Date
- 2020-06-16
- Last Posted Date
- 2021-11-03
- Lead Sponsor
- IRCCS Policlinico S. Donato
- Target Recruit Count
- 40
- Registration Number
- NCT04434001
- Locations
- 🇮🇹
IRCCS Policlinico San Donato, San Donato Milanese, MI, Italy
Comparison of Fibrinogen Concentrate and Cryoprecipitate in Pediatric Cardiac Surgery Patients
- First Posted Date
- 2020-05-06
- Last Posted Date
- 2023-10-23
- Lead Sponsor
- University of Virginia
- Target Recruit Count
- 30
- Registration Number
- NCT04376762
- Locations
- 🇺🇸
University of Virginia Health System, Charlottesville, Virginia, United States
Use of Fibryga, a Fibrinogen Concentrate in Real World: Retrospective Collection of Clinical Data
- First Posted Date
- 2019-09-27
- Last Posted Date
- 2021-05-13
- Lead Sponsor
- Octapharma
- Target Recruit Count
- 200
- Registration Number
- NCT04106895
- Locations
- 🇫🇷
Le Plessis Robinsin Study Site, Le Plessis-Robinson, France
🇫🇷Nantes Study Site, Nantes, France
🇫🇷Marseille Study Site, Marseille, France
Safety and Efficacy of Fibryga in Congenital Fibrinogen Deficiency
- First Posted Date
- 2019-01-04
- Last Posted Date
- 2024-12-13
- Lead Sponsor
- Octapharma
- Target Recruit Count
- 25
- Registration Number
- NCT03793426
- Locations
- 🇩🇪
Gerinnungszentrum rhein-ruhr, Duisburg, Germany
🇨🇿Fakultní nemocnice Ostrava, Ostrava, Czechia
🇩🇪Gerinnungszentrum Hochtaunus, Hamburg, Germany
Patient Blood Management for Massive Obstetric Hemorrhage
- Conditions
- Interventions
- First Posted Date
- 2018-12-24
- Last Posted Date
- 2021-06-08
- Lead Sponsor
- Angel Augusto Perez Calatayud
- Target Recruit Count
- 100
- Registration Number
- NCT03784794
- Locations
- 🇲🇽
Hospital de Especialidades Del Niño Y La Mujer, Querétaro City, Queretaro, Mexico
The Effects of Fibrinogen Concentrate Infusion on Blood Loss and Allogeneic Blood Conservation in Scoliosis Surgery
- Conditions
- Interventions
- First Posted Date
- 2017-06-12
- Last Posted Date
- 2020-03-02
- Lead Sponsor
- Peking Union Medical College Hospital
- Target Recruit Count
- 102
- Registration Number
- NCT03183479
- Locations
- 🇨🇳
Peking Union Medical College Hospital, Beijing, Beijing, China
Human Fibrinogen Concentrate in Pediatric Cardiac Surgery
- Conditions
- Interventions
- First Posted Date
- 2016-07-04
- Last Posted Date
- 2021-09-16
- Target Recruit Count
- 30
- Registration Number
- NCT02822599
- Locations
- 🇺🇸
Nickalus Children's Hospital f/k/a Miami Children's Hospital, Miami, Florida, United States
🇺🇸Nicklaus Children's Hospital, Miami, Florida, United States
Drug Development Updates
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