伊曲康唑 (Sporanox, Tolsura)

概览

Itraconazole is an antifungal agent used for the treatment of various fungal infections in immunocompromised and non-immunocompromised patients, such as pulmonary and extrapulmonary blastomycosis, histoplasmosis, and onychomycosis.

作用机制

Itraconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Itraconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.

适应症

For the treatment of the following fungal infections in immunocompromised and non-immunocompromised patients: pulmonary and extrapulmonary blastomycosis, histoplasmosis, aspergillosis, and onychomycosis.

• Aspergillosis
• Blastomycosis
• Chromoblastomycosis
• Coccidioidal meningitis
• Esophageal Candidiasis
• Fungal Infections
• Fungal skin infection
• Histoplasmosis
• Onychomycosis
• Oropharyngeal Candidiasis
• Paracoccidioidomycosis
• Penicillium marneffei infection